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Rabbit Anti-UBAC1 Polyclonal Antibody#abs134900

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Description

Catalog-specification	Delivery time	USD price
abs134900-100ug	1-2 Weeks	301.0
abs134900-50ug	1-2 Weeks	201.0

Overview
catalog	abs134900
Other names	The gene 1110033G07Rik, also known as AA407978, codes for a protein called E3 ubiquitin-protein ligase subunit KPC2. This protein is also referred to as GBDR1 or Glialblastoma differentiation-related protein 1. Kip1 ubiquitination-promoting complex protein 2, or Kpc2, is another name for this protein. It is also known as UBA domain-containing protein 1 or UBAC1. The gene is also referred to as OTTHUMP00000022563 or RP11-432J22.3. The protein is part of the KPC complex, which targets the tumor suppressor protein p27Kip1 for degradation through the ubiquitin-proteasome pathway. This complex plays a role in regulating the cell cycle and is important for cell proliferation and survival. In addition to its role in tumor growth and development, the protein has also been implicated in neuronal differentiation and synapse formation. Ubiquitin-associated domain-containing protein 1, or Ubadc1, is another name for this gene. The protein contains a UBA domain, which is important for recognizing and binding to ubiquitinated proteins. This domain is also found in other proteins involved in the ubiquitin-proteasome pathway. The function of Ubadc1 is not well-defined, but it may play a role in protein degradation or trafficking. Overall, the gene 1110033G07Rik is important for regulating cell cycle progression and protein degradation. Its role in tumor growth and differentiation makes it an attractive target for cancer therapeutics. Further research is needed to fully understand the function of this gene and its protein product.
Source	Rabbit
Specificity	The detection of total UBAC1 by the UBAC1 antibody is capable of capturing the endogenous levels of the protein.
Species Reactivity	Human
Antigen	UBAC1
Application	For Western blotting, a dilution range of 1:500 to 1:1000 is recommended. To achieve optimal results for immunofluorescence/immunocytochemistry, dilutions of 1:100-1:500 are recommended. For ELISA using peptide antigens, dilutions of 1:20000-1:40000 are suggested. It is important to keep in mind the recommended dilutions to ensure accurate and reliable results in these assays.
Immunogen	A synthesized peptide.
MW	45 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. We were able to achieve a high level of purification using this method.
Clonality	Polyclonal Antibody
Stability & Storage	20°C。/。
Storage buffer	The Rabbit IgG is suspended in a solution of phosphate buffered saline at a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C. The stability of the IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
Tissue specificity	Ubiquitous.
Celluar localization	Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	Q9BSL1