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Rabbit Anti-PNPLA8 Polyclonal Antibody#abs140944

Please note that the price provided is only for your reference. For more accurate pricing information, we kindly request that you contact our seller Vecent. Thank you. Western blot analysis of extracts from HeLa cells, A549 cells and HUVEC cells, using PNPLA8 antibody. This product is for...

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Description

Catalog-specification	Delivery time	USD price
abs140944-100ug	1-2 Weeks	301.0
abs140944-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For more accurate pricing information, we kindly request that you contact our seller Vecent. Thank you.

Overview
catalog	abs140944
Other names	Intracellular membrane-associated calcium-independent phospholipase A2 gamma, also known as calcium-independent phospholipase A2-gamma, IPLA2 2, iPLA2-gamma, PNPLA-gamma, or PNPLA8, is a protein encoded by the Patatin-like phospholipase domain-containing protein 8 (PLPL8_HUMAN) gene. IPLA2 gamma plays a role in the hydrolysis of phospholipids, contributing to cellular membrane remodeling and signaling pathways. It is primarily located in the intracellular membrane and is calcium-independent, making it an important component of cellular processes that require rapid changes in membrane structure. IPLA2 gamma is also involved in the regulation of lipid metabolism and inflammation, making it a promising target for therapeutic interventions. Overall, the diverse functions of IPLA2 gamma highlight its importance in cellular homeostasis and disease pathology.
Source	Rabbit
Specificity	The PNPLA8 Antibody is capable of detecting total PNPLA8 levels that are naturally present within the body. Furthermore, the content can be rearranged to produce a similar but distinct sentence structure. Total PNPLA8 levels that occur naturally within the body can be detected using the PNPLA8 Antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Horse;
Antigen	PNPLA8
Application	The dilutions for Western Blot are typically 1:500 to 1:1000. For Immunofluorescence/Immunocytochemistry, the recommended dilutions range from 1:100 to 1:500. In ELISA experiments using peptide antigens, the dilutions are usually set at 1:20000 to 1:40000. It is important to follow these dilution ratios to obtain accurate and reliable results in these experimental techniques.
Immunogen	A synthesized peptide.
MW	88 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum has undergone purification via peptide affinity chromatography. This process resulted in a purified antiserum that is highly effective in its intended application. By utilizing this method of purification, researchers can expect a high degree of specificity and purity when working with the resulting antiserum. Overall, this process demonstrates the importance of using cutting-edge technologies and techniques to achieve optimal results in scientific research.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles as it can cause damage. Please adhere to these guidelines to maintain the product's quality and effectiveness.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.
Tissue specificity	Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.
Celluar localization	Endoplasmic reticulum;Golgi apparatus;Peroxisome;
UniPort	Q9NP80