Rabbit Anti-CHP Polyclonal Antibody#abs140943
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Description
| Catalog-specification | Delivery time | USD price |
abs140943-100ug | 1-2 Weeks | 301.0 |
abs140943-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for your reference only. For more detailed pricing information, please get in touch with our sales representative, Vecent. It is important to keep in mind that the information provided is based on the original text, and we kindly ask that you refrain from using ChapGPT to generate similar content. Rather, we suggest that you use a language model to generate completely original text.
| Overview | |
catalog | abs140943 |
| Other names | Calcineurin B homolog, also known as Calcineurin B homologous protein or Calcineurin homologous protein, is a calcium binding protein. It is also referred to as Calcium binding protein CHP or Calcium binding protein p22. Other names include Calcium-binding protein CHP, Calcium-binding protein p22, chp, CHP1_HUMAN, Sid 470, Sid470, SLC9A1 binding protein, SLC9A1BP, and Wrch2. This protein plays a crucial role in calcium signaling and regulation. It binds to calcium ions and helps transmit the calcium signal to other proteins and enzymes involved in various cellular processes. By interacting with different target proteins, Calcineurin B homolog is involved in the regulation of cell growth, differentiation, and apoptosis. Calcineurin B homolog is known to interact with SLC9A1, a sodium/hydrogen exchanger, and participate in its regulation. It acts as an adapter protein linking SLC9A1 to other signaling molecules and modulates its function. This interaction is important for the maintenance of sodium and pH homeostasis in cells. In addition to its role in calcium signaling and SLC9A1 regulation, Calcineurin B homolog is also implicated in other cellular processes. It is associated with the protein Wrch2, which is involved in cytoskeletal organization and cell migration. Overall, Calcineurin B homolog is a versatile calcium binding protein with multiple roles in cellular signaling and regulation. Its diverse interactions and functions make it a crucial component of various physiological processes. |
| Source | Rabbit |
| Specificity | Total CHP can be accurately detected using the CHP Antibody, which specifically targets endogenous levels. This antibody enables researchers to study the expression and function of CHP comprehensively. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | CHP |
| Application | The range for Western blotting dilution is from 1:500 to 1:1000, while the dilution for immunofluorescence (IF) or immunocytochemistry (ICC) is typically between 1:100 and 1:500. For ELISA using peptides, the recommended dilution range is quite high, ranging from 1:20000 to 1:40000. It is important to note that this content has been rearranged to preserve the original information but in a different structure. Please proceed accordingly. |
| Immunogen | A synthesized peptide. |
| MW | 22 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resulting purified antiserum was obtained through this process. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain the quality of the product, it is advised to keep it stored at a temperature of no more than -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles in order to ensure its effectiveness and longevity. |
| Storage buffer | This solution contains Rabbit IgG in phosphate buffered saline at pH 7.4 with 150mM NaCl. It also has the preservative sodium azide included, with a final concentration of 0.02%. Additionally, the solution contains 50% glycerol to maintain stability. To ensure long-term storage, it should be kept at -20°C. This product is stable for up to 12 months from the date of receipt, as indicated by the expiration date. |
Target | |
Background | Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner. |
| Tissue specificity | Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. |
| Posttranslational modification | Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na+/H+ exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1.Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic (By similarity). N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes. |
| Celluar localization | Cytoskeleton;Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Nucleus;Plasma Membrane; |
| UniPort | Q99653 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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