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Rabbit Anti-CCRK Polyclonal Antibody#abs133039

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Description

Catalog-specification	Delivery time	USD price
abs133039-100ug	1-2 Weeks	301.0
abs133039-50ug	1-2 Weeks	201.0

Overview
catalog	abs133039
Description	In order to elicit high-level Shh responses within the developing neural tube, the coordination of various factors is crucial. Working alongside BROMI, this coordination plays a vital role in regulating the structure of the primary cilium. It ensures the proper assembly of the ciliary membrane and axoneme, which ultimately allows for the appropriate activation of GLI2 in response to SHH signaling (as suggested by similarities). Moreover, this process is not limited to structural regulation but also extends to cell growth. A key aspect of this regulation involves the activation of CDK2, a kinase that plays a vital role in controlling the cell cycle. The activation is achieved through the phosphorylation of a specific residue, namely 'Thr-160'. By engaging in these intricate mechanisms, the system ensures the proper functioning and development of the neural tube.
Other names	The protein known as CAK kinase p42, also referred to as CAK-kinase p42, CCRK, CDCH, CDK activating kinase p42, or CDK-activating kinase p42, plays a significant role in cell cycle regulation. It is identified as CDK20_HUMAN and is responsible for activating cyclin-dependent protein kinases (CDKs) essential for cell division. Alongside its involvement in cell cycle progression, this protein is also recognized as cell division protein kinase 20 (cdk20), cyclin-dependent protein kinase H (cdk20), and cyclin kinase activating kinase p42 (CDK-activating kinase p42 or Cyclin-kinase-activating kinase p42). A common sequence motif associated with this protein is PNQALRE. Its complex regulatory activities make CAK kinase p42 crucial for maintaining proper cell division.
Source	Rabbit
Specificity	The CCRK antibody is capable of recognizing the total endogenous levels of CCRK protein in various samples. This detection method is highly reliable and precise, enabling accurate measurement of CCRK expression. With the use of this antibody, researchers can gain deeper insights into the biological functions of CCRK in different cell types and tissues. Overall, the CCRK antibody is an essential tool for investigating the role of this protein in various physiological and pathological settings.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Dog;
Antigen	CCRK
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, and SulfoLink™ Coupling Resin was utilized in the process.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
Celluar localization	Nucleus;
UniPort	Q8IZL9