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Rabbit Anti-Defensin Alpha4 Polyclonal Antibody#abs138049

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Description

Catalog-specification	Delivery time	USD price
abs138049-100ug	1-2 Weeks	301.0
abs138049-50ug	1-2 Weeks	201.0

Overview
catalog	abs138049
Other names	DEF4, also known as corticostatin or DEFA4, is a protein belonging to the defensin family. It is encoded by the DEFA4 gene and is produced from a preproprotein called Defensin, alpha 4. Another name for DEF4 is HNP 4 or HP 4. This protein is involved in the immune response and has antimicrobial properties. Its exact mechanism of action is not fully understood, but it is believed to play a role in defending the body against bacterial and fungal infections. Studies have also suggested its potential involvement in various diseases and conditions, including inflammatory bowel disease and cancer. Further research is needed to uncover the full range of DEF4's functions and therapeutic applications.
Source	Rabbit
Specificity	The Defensin alpha4 Antibody is capable of detecting the overall levels of endogenous Defensin alpha4 protein in the sample being analyzed. This antibody specifically targets Defensin alpha4 and can identify any changes in its expression levels in the experimental setup. By using this antibody, researchers can study the functions and mechanisms of Defensin alpha4, which is involved in several biological processes. Overall, the Defensin alpha4 Antibody is a useful tool for investigating this important protein and understanding its role in various physiological functions.
Species Reactivity	Human;Mouse;Rat
Antigen	Defensin alpha4
Application	The suggested dilutions for Western blotting (WB) range from 1:1000 to 1:3000. Immunohistochemistry (IHC) dilution is recommended at 1:200. For ELISA using peptide, the suggested dilution is between 1:20000 and 1:40000. It is important to note that this content is generated based on the original text information.
Immunogen	Human Defensin alpha4 is the source of a synthesized peptide that has been successfully developed. The peptide has been carefully derived to ensure similarity with the original human Defensin alpha4. The process involved rearranging the amino acid sequence while keeping the essential characteristics intact. This advanced technique allows for the production of a highly similar peptide that retains the functional properties of the original Defensin alpha4. The synthesized peptide holds great potential for various applications in the field of medical research and therapeutics.
MW	10 kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was carried out through the utilization of SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20°C for a period of one year. It is important to avoid any repeated freeze and thaw cycles to maintain the product's stability and effectiveness. Note that improper storage may compromise the quality of the product and affect its performance. Therefore, it is crucial to follow the recommended storage instructions to ensure the product's integrity.
Storage buffer	The rabbit IgG is kept in a solution of phosphate buffered saline with pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20°C, and it can remain stable for up to 12 months from the date of receipt.
Target
Background	Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Lysosome;
UniPort	P12838