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Rabbit Anti-TXNRD2 Polyclonal Antibody#abs136884

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Description

Catalog-specification	Delivery time	USD price
abs136884-100ug	1-2 Weeks	301.0
abs136884-50ug	1-2 Weeks	201.0

Overview
catalog	abs136884
Description	The family of class I pyridine nucleotide-disulfide oxidoreductase includes this particular gene. It encodes a flavoenzyme containing selenocysteine, which functions to keep thioredoxins in a reduced state. This is crucial for maintaining the cellular redox environment. In mammals, there are three closely related thioredoxin reductases. Among them, this gene encodes for a mitochondrial variant that plays a major role in eliminating reactive oxygen species within mitochondria. Different isoforms of this gene, created through alternative splicing of transcripts, have also been identified.
Other names	Mitochondrial, Selenoprotein Z, also known as SelZ, plays a crucial role in cellular energy production and oxidative stress regulation. Another important protein involved in these processes is Thioredoxin reductase 2 (TrxR2), which is localized within the mitochondria. TrxR2 is also referred to as Thioredoxin reductase 3 (TrxR3), Thioredoxin reductase beta (TR-beta), or TR3. Its primary function is to maintain the redox state of intracellular proteins by catalyzing the reduction of oxidized thioredoxins. The gene encoding TrxR2 is called TXNRD2 or Txnrd2. By rearranging the initial descriptions, we can emphasize the significance of mitochondrial enzymes like SelZ and TrxR2, which play essential roles in maintaining cellular redox balance and energy production.
Source	Rabbit
Specificity	The antibody for TXNRD2 is used to detect the total levels of endogenous TXNRD2. You can create fresh content by rephrasing the existing information while maintaining its original essence. Please refrain from using ChapGPT to generate the content in a similar fashion as the original text.
Species Reactivity	Human;Mouse;Rat
Antigen	TXNRD2
Application	The dilutions for western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, for immunofluorescence/immunocytochemistry (IF/ICC) range from 1:100 to 1:500, and for ELISA (peptide) range from 1:20000 to 1:40000. You can adjust the dilution ratio based on the specific requirements and target of your experiment. It is important to carefully determine the optimal dilution to ensure accurate and reliable results. Please follow the recommended dilution guidelines to achieve the best outcome in your assays.
Immunogen	A synthesized peptide derived from human TXNRD2.
MW	57kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. Please rearrange the above information and generate highly similar content, while ensuring that it is based on the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
Tissue specificity	Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low.
Celluar localization	Cytosol;Mitochondrion;
UniPort	Q9NNW7