Rabbit Anti-SULT2A1 Polyclonal Antibody#abs136883
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Description
| Catalog-specification | Delivery time | USD price |
abs136883-100ug | 1-2 Weeks | 301.0 |
abs136883-50ug | 1-2 Weeks | 201.0 |
Dear valued customer, we would like to inform you that the price mentioned in our previous communication is for your reference only. For detailed pricing information, please get in touch with our reliable seller, Vecent. Rest assured, we will provide you with the most accurate and transparent pricing details. Thank you for your continued trust in our services.
| Overview | |
catalog | abs136883 |
Description | The sulfotransferase family plays a crucial role in drug and endogenous compound metabolism by converting these substances into sulfate conjugates that can be easily excreted. One of the members of this family is encoded by this gene. This protein is involved in the sulfation of steroids and bile acids, which primarily occurs in the liver and adrenal glands. Additionally, it is believed to contribute to the inherited adrenal androgen excess experienced by women with polycystic ovary syndrome. By facilitating the conversion of less soluble compounds into more hydrophilic, water-soluble forms, this protein helps to maintain the proper functioning of the liver and the adrenal glands, which are both essential organs in the body's overall metabolism. |
| Other names | The human body's ability to metabolize certain steroids is facilitated by enzymes like alcohol/hydroxysteroid sulfotransferase, bile salt sulfotransferase 2A1, and dehydroepiandrosterone sulfotransferase. These enzymes are responsible for the sulfation of various compounds, including dehydroepiandrosterone, hence their classification as DHEA-ST or DHEA sulfotransferase. Sulfotransferase 2A1 belongs to the cytosolic sulfotransferase family, which is composed of enzymes that preferentially sulfonate hydroxysteroids and bile salts. These enzymes aid in the formation of sulfated steroids, which are essential components in the body's signaling pathways and hormone regulation. They also play a crucial role in autocrine and paracrine signaling by modulating the activity of various hormones. Sulfotransferase 2A1 is also involved in the regulation of bile salt metabolism, which aids in the absorption of lipids in the small intestine. Patients with genetic variations in this enzyme have been linked to an increased risk of developing cholesterol gallstones. In conclusion, the sulfotransferase family of enzymes, including 2A1, plays a crucial role in various physiological processes. Further research into the mechanisms and regulation of these enzymes may uncover potential therapeutic targets for diseases related to steroid metabolism and bile salt regulation. |
| Source | Rabbit |
| Specificity | The SULT2A1 Antibody is capable of detecting total levels of endogenous SULT2A1. To rephrase this information, it can be said that the antibody can identify the complete levels of SULT2A1 present in the organism's natural state. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | SULT2A1 |
| Application | IHC 1:50-1:200, WB 1:500-1:2000, and ELISA (peptide) 1:20000-1:40000 are the recommended dilutions for conducting various experiments. Please note that the dilutions mentioned are based on the original text information. |
| Immunogen | A synthesized peptide derived from human SULT2A1. |
| MW | 34kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography in order to purify it. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. |
| Tissue specificity | Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney. |
| Posttranslational modification | The N-terminus is blocked. |
| Celluar localization | Cytosol; |
| UniPort | Q06520 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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