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Rabbit Anti-PROS1 Polyclonal Antibody#abs136007

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Description

Catalog-specification	Delivery time	USD price
abs136007-100ug	1-2 Weeks	301.0
abs136007-50ug	1-2 Weeks	201.0

Overview
catalog	abs136007
Description	This particular gene is responsible for producing a plasma protein that plays a crucial role in blood coagulation. Specifically, it acts as a cofactor for activated protein C (APC), an anticoagulant protease that inhibits the formation of blood clots. The protein is present in the plasma in two forms: an active form that is free to carry out its functions, and an inactive form that is bound to C4b-binding protein. Mutations in this gene are associated with a type of hereditary thrombophilia, where affected individuals have an increased risk of developing blood clots. It is worth noting that there is also a non-functional pseudogene of this gene located nearby on chromosome 3. This information is sourced from RefSeq and was last updated in February 2009.
Other names	Protein S, also known as vitamin K-dependent protein S or vitamin K-dependent plasma protein S, is a crucial molecule involved in coagulation. It exists in a variety of forms, including preproprotein S, which is the propiece of latent protein S. PROS 1, PROS, PROS_HUMAN, proS1, Protein S alpha, Protein Sa, PS 21-26, PSA, THPH5, and THPH6 are all other names for protein S, with each name representing a different isoform or variant. Protein S plays a critical role in preventing blood clotting by acting as a cofactor to activated protein C. Without protein S, blood clots can form easily, increasing the risk of thrombotic events such as deep vein thrombosis and pulmonary embolism. In addition to its role in coagulation, protein S also has anti-inflammatory properties, which may help to protect against vascular disease. Overall, protein S is a complex and essential molecule with a variety of isoforms and functions. Its role in coagulation and inflammation underscores the importance of maintaining proper levels of this protein in the bloodstream.
Source	Rabbit
Specificity	The PROS1 Antibody is capable of detecting the total endogenous levels of PROS1.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep
Antigen	PROS1
Application	The recommended dilutions for Western blot (WB) range from 1:500 to 1:2000. For immunohistochemistry (IHC), the dilutions recommended are 1:50 to 1:200. For immunofluorescence/immunocytochemistry (IF/ICC), the dilutions suggested are 1:100 to 1:500. Lastly, for ELISA (peptide), the dilutions vary from 1:20000 to 1:40000. Please note that these dilutions have been provided based on the original content and should be followed accordingly.
Immunogen	A synthesized peptide derived from human PROS1.
MW	70kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Tissue specificity	Plasma.
Posttranslational modification	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	P07225