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Rabbit Anti-Renin Polyclonal Antibody#abs137191

Description

Catalog-specification	Delivery time	USD price
abs137191-100ug	1-2 Weeks	301.0
abs137191-50ug	1-2 Weeks	201.0

Please note that the price provided is for your reference only. For detailed pricing information, please reach out to our seller, Vecent. It is important to emphasize that any content generated should be based on the original text information but should be rearranged to create unique text. Let's refrain from following the conversational style generated by ChapGPT and instead speak in a completely different manner using language modeling.

Overview
catalog	abs137191
Other names	Renin, also known as angiotensinogenase or angiotensin forming enzyme, is an important enzyme involved in the regulation of blood pressure and fluid balance in the body. It is encoded by the REN gene and is synthesized as a precursor molecule known as prorenin. FLJ10761, HNFJ2, and REN1 are alternative names or aliases for the REN gene. The protein produced by this gene is called renin and is secreted by specialized cells in the kidneys called juxtaglomerular cells. The primary function of renin is to convert angiotensinogen, a protein produced by the liver, into angiotensin I. Angiotensin I is then further converted into angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, meaning it causes blood vessels to constrict, thereby increasing blood pressure. Renin is regulated by various factors including blood pressure, fluid balance, and sympathetic nervous system activity. When blood pressure is low or fluid volume is depleted, the juxtaglomerular cells release renin into the bloodstream. Renin then acts on angiotensinogen to initiate the renin-angiotensin-aldosterone system, a hormonal cascade that helps restore blood pressure and fluid balance. In conclusion, renin, also known as angiotensinogenase, is a crucial enzyme involved in the regulation of blood pressure and fluid balance. It is encoded by the REN gene and acts on angiotensinogen to produce angiotensin I, which is further converted into angiotensin II. This enzyme plays a vital role in maintaining cardiovascular homeostasis.
Source	Rabbit
Specificity	The Renin Antibody is designed to detect the total Renin levels present naturally in the body.
Species Reactivity	Human;Mouse
Antigen	Renin
Application	WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000. Here are the revised content based on the original information: - For Western Blotting (WB), the recommended dilution range is 1:1000 to 1:3000. - Immunohistochemistry (IHC) is best performed at a dilution of 1:200. - If you are conducting Immunofluorescence or Immunocytochemistry (IF/ICC), it is recommended to dilute the primary antibody at a range of 1:100 to 1:500. - When using ELISA for peptide detection, a dilution range of 1:20000 to 1:40000 is suggested. Please note that these dilution ratios provide optimal results and may vary depending on the specific experiment and target protein.
Immunogen	A synthesized peptide derived from human Renin.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, and SulfoLink™ Coupling Resin was utilized for this process. Let's not rely on ChapGPT for generating similar content, but instead employ a language model to produce a completely different discourse.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of your product, it is recommended that you store it at a temperature of -20 °C for a period of one year. Please take care to avoid any instances of repeated freeze/thaw cycles, as this can negatively impact the quality of your product over time. By adhering to these guidelines, you can help to preserve the efficacy and stability of your product for long-term use.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline at a pH of 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage, it is recommended to keep this product at a temperature of -20°C. The solution is stable for a period of 12 months from the date of receipt and should be protected from light. This highly purified Rabbit IgG product is an ideal component for various research applications.
Target
Background	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P00797