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Rabbit Anti-CREM Polyclonal Antibody#abs133539

Description

Catalog-specification	Delivery time	USD price
abs133539-50ug	1-2 Weeks	201.0
abs133539-100ug	1-2 Weeks	301.0

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Overview
catalog	abs133539
Other names	CREM (cAMP response element modulator) is a protein that plays a significant role in cellular function. It acts as a modulator of cAMP (cyclic adenosine monophosphate) response elements. The cAMP-responsive element modulator, also known as CREM-2 or hCREM 2, is a variant of CREM found in humans. Another name for this protein is Inducible cAMP early repressor (ICER). ICER is responsible for regulating gene expression by binding to cAMP response elements. In addition to its role as a modulator, CREM also functions as an inducible cAMP early repressor, further highlighting its importance in cellular processes. Notably, the proteins MGC111110, MGC17881, and MGC41893 are alternative names or aliases for CREM. They refer to the same protein but are used in different contexts or research settings.
Source	Rabbit
Specificity	Total CREM levels in a biological sample can be accurately measured using the CREM Antibody, which specifically detects the endogenous levels of CREM. By utilizing this antibody, researchers can assess the overall expression of CREM and gain insights into its biological functions and regulatory mechanisms.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;
Antigen	CREM
Application	For Western blotting, we recommend diluting your primary antibody at a ratio of 1:500 to 1:1000. If you are using immunofluorescence or immunocytochemistry, we suggest diluting your antibody at 1:100 to 1:500. For ELISA using a peptide, we suggest using a dilution of 1:20000 to 1:40000. Please keep in mind these recommended dilutions when using our antibodies for these applications.
Immunogen	A synthesized peptide.
MW	34 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was utilized to purify the antiserum. Let's generate a highly similar content by rearranging the above information, ensuring it is based on the original text: In the purification process of the antiserum, SulfoLink™ Coupling Resin was employed for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, keep the product at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting it to repeated cycles of freezing and thawing.
Storage buffer	The storage condition for Rabbit IgG is a phosphate buffered saline solution with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The product is stable for a period of 12 months from the date it is received.
Target
Background	Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Tissue specificity	Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Posttranslational modification	Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.Stimulated by phosphorylation.
Celluar localization	Nucleus;
UniPort	Q03060