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Rabbit Anti-MEF2B Polyclonal Antibody#abs133538

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Description

Catalog-specification	Delivery time	USD price
abs133538-100ug	1-2 Weeks	301.0
abs133538-50ug	1-2 Weeks	201.0

Overview
catalog	abs133538
Other names	MADS box transcription enhancer factor 2, also known as MEF2B, Myocyte enhancer factor 2B, or Myocyte-specific enhancer factor 2B, is a protein that plays a crucial role in enhancing transcription in a variety of cell types. It is also referred to as MDS1 EVI1, PRDM3, or RSRFR2, and XMEF2. This transcription factor is highly conserved across species, and variations in its expression or function have been linked to various diseases, including cancer, neurological disorders, and cardiovascular diseases. MEF2B belongs to a family of transcription factors, the MEF2 family, which consists of four members (MEF2A, MEF2B, MEF2C, and MEF2D). These factors help to regulate the development and function of various tissues in the body, including those of the heart, skeletal muscle, and brain. MEF2B is particularly important for the development of muscle tissue and the maintenance of muscle function throughout life. In addition to its role in muscle development and function, MEF2B has also been shown to play a role in regulating gene expression in other tissues, including the brain, immune system, and blood vessels. As such, variations in MEF2B expression or function have been associated with various diseases, including cancer, Alzheimer's disease, and cardiovascular diseases such as atherosclerosis. Overall, MEF2B is a crucial transcription factor that plays a critical role in a variety of biological processes. Its dysregulation has been linked to various diseases, and further studies are needed to fully understand its function and potential therapeutic applications.
Source	Rabbit
Specificity	Total endogenous levels of MEF2B can be detected using the MEF2B Antibody. To generate a similar content by rearranging the information: The MEF2B Antibody provides the means to detect total endogenous levels of MEF2B.
Species Reactivity	Human;Mouse
Antigen	MEF2B
Application	The dilution range for Western blot (WB) is 1:500 to 1:1000, while for immunofluorescence (IF) and immunocytochemistry (ICC) it is 1:100 to 1:500. For ELISA assays using peptide antigens, the recommended dilution is 1:20000 to 1:40000. It is important to note that this generated content is based on the original text information, albeit rearranged.
Immunogen	A synthesized peptide.
MW	38 KD
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. This process resulted in a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum efficacy, it is recommended to store this product at a temperature of -20 °C for up to one year. It is important to avoid exposing it to repeated freeze/thaw cycles, as this may compromise its stability over time. Taking these precautions will help preserve the quality and potency of the product, ensuring that it remains effective for its intended use.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to keep this product at a temperature of -20°C, where it will remain stable for up to 12 months from the date of receipt. With these storage conditions, you can be assured of the long-term integrity and effectiveness of the Rabbit IgG.
Target
Background	Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Tissue specificity	Expressed in skeletal and cardiac muscle and brain.
Celluar localization	Nucleus;
UniPort	Q02080