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Rabbit Anti-RASGRF1 Polyclonal Antibody#abs137503

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Description

Catalog-specification	Delivery time	USD price
abs137503-100ug	1-2 Weeks	301.0
abs137503-50ug	1-2 Weeks	201.0

Overview
catalog	abs137503
Other names	There are several different names and aliases for the protein RASGRF1, which is a guanine nucleotide exchange factor that plays a role in signal transduction pathways. Some of these aliases include CDC25, CDC25L, GNRP, GRF1, GRF55, HGRF55, and PP13187. RASGRF1 is also known as Ras specific guanine nucleotide releasing factor 1, Ras-specific nucleotide exchange factor CDC25, and Ras-GRF1. Regardless of what it is called, RASGRF1 functions to activate the GTPases that are involved in various cellular processes. Its involvement in signal transduction pathways makes it an important target for drug development and therapeutic intervention.
Source	Rabbit
Specificity	The RASGRF1 Antibody is capable of detecting the total amount of endogenous RASGRF1 levels. You can create similar content by reordering the original text information.
Species Reactivity	Human
Predictive reaction species	Rabbit;Pig;Dog;Bovine;Horse
Antigen	RASGRF1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RASGRF1.
MW	145 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Promotes the exchange of Ras-bound GDP by GTP.
Posttranslational modification	Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome.Ubiquitinated and degraded following phosphorylation by PLK2.Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q13972