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Rabbit Anti-TRPM2 Polyclonal Antibody#abs137019

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Description

Catalog-specification	Delivery time	USD price
abs137019-100ug	1-2 Weeks	301.0
abs137019-50ug	1-2 Weeks	201.0

Overview
catalog	abs137019
Other names	Estrogen responsive element associated gene 1 (EREG1) is a protein that plays a role in response to estrogen. It was also identified as a putative calcium channel protein (NUDT9H) and a member of the transient receptor potential (TRP) cation channel subfamily M (TRPM2). EREG1 is also known as long TRP channel 2 (LTRPC2) and TRP channel 7 (TRPC7), as it has multiple aliases. It is encoded by the KNP3 gene (KNP3/MGC133383/NUDT9L1). EREG1 is a crucial protein that is involved in a variety of physiological and pathological processes, such as cell proliferation, differentiation, and death.
Source	Rabbit
Specificity	The TRPM2 Antibody is capable of detecting the complete levels of endogenous TRPM2 protein present in a sample. The content can be rephrased as follows, ensuring the original information is incorporated: By targeting endogenous TRPM2, the TRPM2 Antibody can accurately measure the total levels of this protein within a given sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine;Sheep;
Antigen	TRPM2
Application	The recommended dilution for WB is between 1:1000 to 1:3000, while for IHC it is advised to use a dilution of 1:200. For ELISA using peptide, the recommended dilution is between 1:20000 to 1:40000. It is important to follow these dilution guidelines to achieve optimal results in your experiments.
Immunogen	A synthesized peptide derived from human TRPM2.
MW	171 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed for the purification of the antiserum. You can expect the content to be highly similar to the original text, as the information provided is rearranged.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of this product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to note that the product should be kept away from repeated freeze/thaw cycles, as this can compromise its quality.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Isoform 1: Nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:27383051, PubMed:27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed:19171771). Also contributes to Ca2+ release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca2+ levels (Probable). Besides, mediates the release of lysosomal Zn2+ stores in response to reactive oxygen species, leading to increased cytosolic Zn2+ levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD+) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:27383051, PubMed:27068538). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca2+ levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca2+ levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca2+ and Zn2+ levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606).
Tissue specificity	Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
Celluar localization	Lysosome;Plasma Membrane;
UniPort	O94759