Rabbit Anti-TNF14 Polyclonal Antibody #abs130265

abs130265-50ug

1-2 Weeks

201

abs130265-100ug

1-2 Weeks

301

Description

BTLA receptor is responsible for binding to TNFSF14/LIGHT and TNFSF1/lymphotoxin-alpha, forming a homotrimeric complex. Its role in lymphocyte activation is crucial. In the context of HSV pathogenesis, BTLA receptor has shown to significantly enhance the entry of various wild-type HSV strains from both serotypes into CHO cells. Additionally, it has been observed to facilitate HSV entry into activated human T-cells. The implications of these findings highlight the importance of BTLA receptor in HSV infection and shed light on its potential as a therapeutic target in combating viral diseases.

Other names

LIGHT, also known as CD258 or CD258 antigen, is a protein that serves as a ligand for herpesvirus entry mediator (HVEM). It is involved in the entry of herpes viruses into cells. It is also called Delta transmembrane LIGHT, Herpes virus entry mediator ligand, Herpesvirus entry mediator A, Herpesvirus entry mediator ligand, HVEM L, HVEM-L, HVEML, Ligand for herpesvirus entry mediator, LTg, soluble form, TNF14, TNF14_HUMAN, TNFSF 14, Tnfsf14, TNFSF14 protein, TR 2, TR2, Tumor necrosis factor (ligand) superfamily, member 14, Tumor necrosis factor ligand superfamily member 14, Tumor necrosis factor ligand superfamily, member 14, Tumor necrosis factor receptor like 2, tumor necrosis factor receptor-like 2, Tumor necrosis factor superfamily member 14, and Tumor necrosis factor superfamily member LIGHT.
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Source

Rabbit

Specificity

TNF14 Antibody detects endogenous levels of TNF14

Species Reactivity

Human;Mouse

Application

IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human TNF14

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

Ensure that the product is stored at a temperature of -20 °C for a duration of one year to maintain its quality. It is important to avoid subjecting the product to multiple freeze/thaw cycles as this can negatively impact its stability and effectiveness.

Storage buffer

This product is Rabbit IgG dissolved in phosphate buffered saline (PBS) with a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The product remains stable for a period of 12 months starting from the date of receipt.

Target

Background

LTB is a cytokine that binds to the TNFRSF3 receptor, also known as LTBR. Its effects can be modulated by binding to the decoy receptor TNFRSF6B. This cytokine has been shown to activate NFKB and stimulate the proliferation of T-cells, while also inhibiting the growth of the adenocarcinoma HT-29. Additionally, LTB acts as a receptor for the Herpes simplex virus.

Tissue specificity

Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Posttranslational modification

N-glycosylated.The soluble form of isoform 1 derives from the membrane form by proteolytic processing.

Celluar localization

Extracellular region or secreted;Plasma Membrane;

UniPort

O43557