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Rabbit Anti-CDKAP1 Polyclonal Antibody #abs130245

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Description

Catalog-specification	Delivery time	USD price
abs130245-50ug	1-2 Weeks	201
abs130245-100ug	1-2 Weeks	301

Overview
Description	CDK2AP1 Belongs to the CDK2AP family.
Other names	CDK2 A1, also known as CDK2 associated protein 1 or CDK2AP1, is a crucial protein involved in cell cycle regulation. It plays a significant role in the association and regulation of Cyclin-dependent kinase 2 (CDK2), a key enzyme responsible for cell division and proliferation. CDK2AP1 is encoded by the CDKA1 gene in humans. This protein is also referred to as Cyclin dependent kinase 2 associated protein 1, emphasizing its association with CDK2. Another name for CDK2AP1 is Deleted in Oral Cancer 1 (DOC 1), as it was initially identified as a potential tumor suppressor gene in oral cancer. It is also known as DOC 1 related protein or DOC1R. CDK2AP1, also called DOC-1 or p12DOC 1, is considered a putative oral cancer suppressor due to its potential role in inhibiting cancer cell growth and proliferation. Additionally, CDK2AP1 is associated with ST19, a gene associated with cell differentiation and development. In summary, CDK2AP1 is a versatile protein involved in cell cycle regulation and potentially implicated in oral cancer suppression. Its diverse names reflect its various associations and functions within cellular processes.
Source	Rabbit
Specificity	The CDKAP1 antibody is capable of detecting the complete levels of CDKAP1 that exist naturally within an organism. This content can be rephrased by rearranging the original text, which emphasizes the ability of the antibody to detect total CDKAP1 in its endogenous form.
Species Reactivity	Human;Mouse
Application	WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CDKAP1
Properties
Concentration	1mg/ml
Purification	Affinity-chromatography
Clonality	Polyclonal Antibody
Stability & Storage	One year storage is recommended at -20 °C without subjecting the product to repeated freezing and thawing cycles. It is crucial to avoid exposing the product to fluctuations in temperature to maintain its quality.
Storage buffer	The storage condition for rabbit IgG is at -20 °C in phosphate buffered saline with a pH of 7.4. It should be supplemented with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that it remains stable for a duration of 12 months starting from the date of receipt.
Target
Background	specific inhibitor of the cell-cycle kinase CDK2.
Posttranslational modification	Phosphorylated in vitro by IKBKE at Ser-46.
Celluar localization	Cytosol;Nucleus;
UniPort	O14519