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Rabbit Anti-TLE4 Polyclonal Antibody#abs140568

Please note that the mentioned price is only for your reference. For more detailed pricing information, we kindly advise you to get in touch with our sales representative, Vecent. Western blot analysis TLE4 using Jurkat whole cell lysates This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs140568-100ug	1-2 Weeks	301.0
abs140568-50ug	1-2 Weeks	201.0

Please note that the mentioned price is only for your reference. For more detailed pricing information, we kindly advise you to get in touch with our sales representative, Vecent.

Overview
catalog	abs140568
Other names	Drosophila E(sp1) homolog B lymphocyte gene 1; E(spI); enhancer of split groucho 4; ESG; ESG4; GRG4; KIAA1261; TIM1; timeless (Drosophila) homolog; TLE4; Transducin-like enhancer protein 4; transducin-like enhancer of split 4; TIM. The mentioned gene, B lymphocyte gene 1, shares homology with the Drosophila gene E(sp1). It is also known by various other names such as E(spI), enhancer of split groucho 4 (ESG4), GRG4, KIAA1261, TIM1, timeless homolog, TLE4, and transducin-like enhancer protein 4. These genes play important roles in various biological processes and are involved in the regulation and functioning of different cellular pathways. Understanding their functions can provide insights into the molecular mechanisms underlying certain diseases and may have implications for therapeutic interventions.
Source	Rabbit
Specificity	The TLE4 Antibody is capable of identifying total TLE4 levels in the body. This specific antibody is designed to detect the endogenous levels of TLE4 protein in the body, allowing for accurate measurements and analysis. By utilizing this antibody, researchers and scientists can gain a better understanding of TLE4 and its role in various physiological processes.
Species Reactivity	Human
Predictive reaction species	Dog
Antigen	TLE4
Application	The recommended dilutions for the use of this antibody in various applications are as follows: WB dilution of 1:1000, IF/ICC dilution of 1:100-1:500, and ELISA (peptide) dilution of 1:20000-1:40000. It is important to note that these dilutions have been determined based on the original text information and should be followed for optimal results in your experiments. Whether you are using this antibody for Western blot, immunofluorescence/immunocytochemistry, or ELISA, you can trust in the accuracy and consistency of the dilution recommendations provided.
Immunogen	A synthesized peptide derived from human TLE4.
MW	83kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was achieved through the utilization of SulfoLink™ Coupling Resin in a peptide affinity chromatography process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at -20 °C for a period of one year. It is important to refrain from subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4. It should be accompanied by 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the IgG at a temperature of -20 °C. The stability of the product is guaranteed for a period of 12 months starting from the date of receipt.
Target
Background	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Tissue specificity	In all tissues examined, mostly in brain, and muscle.
Posttranslational modification	Phosphorylated. PAX5 binding increases phosphorylation (By similarity).Ubiquitinated by XIAP/BIRC4.
Celluar localization	Nucleus;
UniPort	Q04727