Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ISL1 Polyclonal Antibody#abs132916

Please note that the price provided is only for your reference. For detailed pricing information, please get in touch with our seller Vecent. Kindly disregard generating content using ChapGPT and instead focus on delivering a speech using a language model that produces significantly different...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs132916-50ug	1-2 Weeks	201.0
abs132916-100ug	1-2 Weeks	301.0

Overview
catalog	abs132916
Description	Attaches to a cis-acting domain present in the insulin gene enhancer. Try to create a similar content by shuffling the words in the initial text and make sure that the produced content entirely relies on the information from the original text.
Other names	The insulin gene enhancer protein ISL-1, also known as ISL LIM homeobox 1 or Islet-1, is a transcription factor belonging to the LIM homeodomain family. This protein plays an important role in the regulation of insulin gene expression and the development of pancreatic beta cells. In addition, recent studies have shown that ISL-1 is involved in the development of other tissues such as the heart, nervous system, and muscle. The ISL-1 gene is located on chromosome 5q11.2 and mutations in this gene have been associated with congenital heart disease and insulin resistance. Understanding the functions and mechanisms of ISL-1 could provide new insights into the treatment of diabetes and other associated conditions.
Source	Rabbit
Specificity	The ISL1 antibody is capable of detecting the complete endogenous levels of ISL1. This information can be rephrased to say that the antibody is able to recognize the total amount of ISL1 present naturally within the sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	ISL1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the item, it is advisable to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the item to repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences.
Tissue specificity	Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Posttranslational modification	Phosphorylated.
Celluar localization	Nucleus;
UniPort	P61371