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Rabbit Anti-TDGF1 Polyclonal Antibody#abs135730

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis of NCCIT cell lysate using TDGF1 antibody. This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs135730-100ug	1-2 Weeks	301.0
abs135730-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs135730
Description	TDGF-1, also known as Cripto, is a member of the EGF-CFC family of proteins that plays a significant role in embryogenesis and oncogenesis. This protein contains a conserved cysteine-rich domain (CFC motif) and a hydrophobic carboxy-terminal tail that facilitates its attachment to the extracellular plasma membrane via a GPI moiety. The O-linked fucosylation site within the EGF-like motif is necessary for Cripto to function as a coreceptor for TGF-β-related ligands such as Nodal and Vg1/GDF1. Besides, Cripto also has paracrine activity and acts as a co-ligand for Nodal. Cripto is highly expressed in early embryos and embryonic stem cells, where it plays significant roles in cardiomyocytic differentiation and negatively regulates neurogenesis. The protein positively regulates stem cell self-renewal and pluripotency, and its transient activation is essential for maintaining these properties in embryonic and adult-derived stem cells. Cripto is a potent oncogene that promotes tumorigenesis by stimulating various activities such as proliferation, cell motility, invasion, angiogenesis, and epithelial-mesenchymal transition (EMT). It is highly expressed in a broad range of tumors, highlighting its importance as a therapeutic target in cancer.
Other names	Cripto, also known as TDGF1 or CRGF, is a growth factor that plays an important role in embryonic development and cancer progression. This protein is also referred to as Cripto-1 growth factor and has been shown to have epidermal growth factor-like properties. Additionally, it is implicated in the growth and migration of many types of cancer cells, making it a promising target for cancer therapy. Although much is known about the function of Cripto, there is still much to learn about its complex biology and interactions with other molecules within the body. Nevertheless, ongoing research continues to shed light on this fascinating protein and its potential as a therapeutic target.
Source	Rabbit
Specificity	The TDGF1 Antibody is capable of detecting the overall levels of endogenous TDGF1 in a sample. This means that the antibody can identify the total amount of TDGF1 present in the sample, without distinguishing between different forms or variants.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine;Rabbit;
Antigen	TDGF1
Application	WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TDGF1.
MW	21kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Tissue specificity	Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P13385