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Rabbit Anti-TAOK1 Polyclonal Antibody#abs134778

Please note that the price provided is only for your reference. To obtain detailed pricing information, please reach out to our sales representative, Vecent. We urge you to ask Vecent for a complete breakdown of the costs. Western blot analysis of extracts from NIH/3T3 cells, using TAOK1...

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Description

Catalog-specification	Delivery time	USD price
abs134778-100ug	1-2 Weeks	301.0
abs134778-50ug	1-2 Weeks	201.0

Overview
catalog	abs134778
Other names	The gene 2810468K05Rik, also known as AU020252 or D130018F14Rik, encodes for the protein kinase TAO1, which belongs to the STE20-like kinase family. TAO1 is also referred to as MAP3K16, MARK kinase, or PSK2, and has multiple aliases such as KIAA1361, mKIAA1361, or Microtubule affinity regulating kinase kinase. It is involved in various cellular processes, including the regulation of cell growth, division, and apoptosis. TAO1 plays a crucial role in the regulation of microtubule dynamics, which is important for maintaining proper cell division and motility. It is also involved in the activation of the JNK signaling pathway, which is essential for immune responses and cell survival. Additionally, TAO1 has been implicated in the development of multiple types of cancer, including breast, lung, and pancreatic cancer. The human TAOK1 protein has a length of 1,119 amino acids and is highly conserved across species. Its structure includes a kinase domain and a coiled-coil domain, which are important for protein-protein interactions and kinase activation. Furthermore, TAO1 is regulated by various upstream kinases, including MST3 and LATS, as well as by post-translational modifications such as phosphorylation and ubiquitination. In conclusion, TAO1 is a multifunctional protein kinase that plays important roles in various cellular processes and is implicated in cancer development. Further studies on its regulation and function may provide insights into the development of novel therapeutic strategies for cancer treatment.
Source	Rabbit
Specificity	The TAOK1 Antibody can detect total TAOK1 levels that are naturally present in the body. To produce similar content, the information from the original text can be rephrased such as "Total TAOK1 levels that are naturally occurring in the body can be identified using the TAOK1 Antibody."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	TAOK1
Application	For western blotting, we recommend a dilution range of 1:500 to 1:1000. When performing immunohistochemistry, a dilution range of 1:50 to 1:200 is suitable. Dilute the antibody 1:100 to 1:500 for immunofluorescence and immunocytochemistry applications. For ELISA using peptide, a dilution range of 1:20000 to 1:40000 is recommended. To ensure the best results, adjust the dilution according to the specific experimental conditions and sample type.
Immunogen	A synthesized peptide.
MW	120 KD
Properties
Concentration	1mg/ml
purification	Using the SulfoLink™ Coupling Resin, we performed peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Tissue specificity	Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
Posttranslational modification	Proteolytically processed by caspase-3 (CASP3).Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	Q7L7X3