Rabbit Anti-AZI2 Polyclonal Antibody #abs130414

abs130414-50ug

1-2 Weeks

201

abs130414-100ug

1-2 Weeks

301

Description

A protein called AZI2 plays an important role in the activation and regulation of serine/threonine-protein kinase TBK1. It facilitates the oligomerization of TBK1, helping to form functional complexes. Additionally, AZI2 enhances the phosphorylation of the NF-kappa-B p65 subunit RELA by TBK1. This phosphorylation event is crucial for the activation of NF-kappa-B and its downstream signaling pathways.
AZI2 is involved in multiple signaling pathways that lead to NF-kappa-B activation. It promotes TBK1-induced activation of NF-kappa-B, as well as activation induced by TNF-alpha or PMA. These stimuli can trigger AZI2-dependent signaling cascades, resulting in the activation and nuclear translocation of NF-kappa-B.
Furthermore, AZI2 participates in the activation of the IFN-beta promoter via its interaction with TICAM1. TICAM1 is a crucial adaptor molecule involved in the innate immune response. The interaction between AZI2 and TICAM1 contributes to the activation of the IFN-beta promoter, leading to the production of interferons that play a critical role in antiviral defenses.
In terms of protein interactions, AZI2 interacts with IKBKE, TBK1, and TICAM1. These interactions likely facilitate the formation of protein complexes involved in signaling pathways leading to NF-kappa-B activation and IFN-beta production.
It is worth mentioning that alternative splicing generates two isoforms of the human AZI2 protein. The presence of multiple isoforms suggests the possibility of diverse functions or regulatory mechanisms associated with AZI2.
To summarize, AZI2 is an important regulator in various signaling pathways involved in NF-kappa-B activation and innate immune responses. It interacts with key proteins such as TBK1, TICAM1, and IKBKE to facilitate their functions and promote downstream signaling events. The existence of different isoforms further highlights the complexity and versatility of AZI2's role in cellular processes.

Other names

Here are some options for highly similar content:
1. AZI2, also known as 5-azacytidine induced protein 2, Nak associated protein 1, or NF-kappa-B-activating kinase-associated protein 1, is a protein involved in regulating immune response and inflammation. It is encoded by the AA410145 gene and also goes by the names AZ2, AZI2_HUMAN, MGC112644, TILP, and TILP(S).
2. The protein AZI2, also called 5-azacytidine-induced protein 2 or NF kappa B activating kinase associated protein 1, plays a role in the immune system and is associated with the AA410145 gene. It is sometimes referred to as Nak associated protein 1, TILP, TILP(S), AZ2, or MGC112644.
3. AZI2, or Nak-associated protein 1, is a protein encoded by the AA410145 gene that is involved in regulating the immune system. It is also known as 5-azacytidine-induced protein 2, NF-kappa-B-activating kinase-associated protein 1, TILP, TILP(S), AZ2, or MGC112644.

Source

Rabbit

Specificity

AZI2 Antibody detects endogenous levels of AZI2

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human AZI2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that the product should not be subjected to repeated freeze and thaw cycles as this may compromise its efficacy and stability. Therefore, it is best to follow the storage guidelines to ensure that the product remains suitable for use over an extended period of time.

Storage buffer

The Rabbit IgG is stored in a solution consisting of phosphate buffered saline with a pH of 7.4, 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, as it is stable for up to 12 months from the date of receipt. It is important to ensure that the generated content is based on the original text information while rearranging its structure to produce a highly similar content.

Target

Background

This adapter protein is a crucial component of the antiviral innate immunity system. It plays a critical role by binding to TBK1 and IKBKE and facilitating their activation. It also promotes the oligomerization of TBK1 and enhances the phosphorylation of RELA, which is a subunit of NF-kappa-B. It can activate NF-kappa-B via TBK1 or through TNF-alpha or PMA stimulation. Moreover, it is implicated in IFNB promoter activation, and it achieves this by interacting with TICAM1. Overall, this adapter protein has a significant role in innate immunity and the activation of the NF-kappa-B pathway.

Tissue specificity

The pancreas and testis exhibit an abundant expression of this gene, which is widely observed throughout various tissues.

UniPort

Q9H6S1