Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-SOD-3 Polyclonal Antibody#abs137230

Please be informed that the price mentioned above is only provided for your reference. For detailed pricing, we kindly recommend you to get in touch with our seller Vecent. Please note that the content generated should be significantly different from the original text, as per your request to...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs137230-100ug	1-2 Weeks	301.0
abs137230-50ug	1-2 Weeks	201.0

Overview
catalog	abs137230
Other names	Extracellular superoxide dismutase, also known as EC-SOD or SOD3, is an important enzyme involved in the defense against oxidative stress. It plays a crucial role in neutralizing harmful superoxide radicals in the extracellular space. The full name of this enzyme is extracellular superoxide dismutase [Cu Zn], and it exists as a precursor before being processed into its mature form. One of the aliases for this enzyme is MGC20077, which is its designation in the Mammalian Gene Collection. This enzyme is primarily found in the extracellular matrix of various tissues, including the lungs, blood vessels, and reproductive organs. The function of extracellular superoxide dismutase is to convert superoxide radicals into hydrogen peroxide, which is less harmful to cells. This process requires copper and zinc as cofactors, hence the designation [Cu Zn]. The mature form of SOD3 is generated by the removal of a signaling peptide sequence from the precursor protein. Superoxide dismutase 3 plays a crucial role in maintaining the balance between oxidants and antioxidants in the extracellular environment. By neutralizing superoxide radicals, it helps protect cells and tissues from oxidative damage. Oxidative stress has been associated with various diseases, including cardiovascular disorders, neurodegenerative conditions, and inflammation. Therefore, SOD3 is considered an important enzyme for maintaining overall health and preventing oxidative damage. In summary, extracellular superoxide dismutase [Cu Zn], also known as SOD3 or EC-SOD, is a vital enzyme involved in the defense against oxidative stress. Its function is to neutralize superoxide radicals by converting them into hydrogen peroxide. This enzyme is found in various tissues and plays a crucial role in maintaining the oxidant-antioxidant balance in the extracellular environment.
Source	Rabbit
Specificity	The antibody, SOD-3 Antibody, is capable of detecting the total SOD-3 in a sample, specifically targeting endogenous levels of the protein. By recognizing and binding to SOD-3, this antibody allows for the measurement and analysis of the protein's presence.
Species Reactivity	Human;Mouse;Rat
Antigen	SOD-3
Application	Here's an alternative version: To use our antibody products effectively, we recommend diluting them at a ratio of 1:1000 to 1:3000 for Western blotting applications, or at a dilution ratio of 1:100 to 1:500 for immunofluorescence/immunocytochemistry experiments. For peptide-based ELISAs, a dilution of 1:20000 to 1:40000 is ideal. These guidelines will help to ensure that you achieve the best possible results with our antibodies.
Immunogen	A synthesized peptide derived from human SOD-3.
MW	26 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. A highly similar content can be generated by rearranging the above information, maintaining the original text's details.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze/thaw cycles as this can impact its quality. By following these storage recommendations, you can help to extend the shelf life of the product and maintain its integrity over time.
Storage buffer	The Rabbit IgG solution is composed of 150mM NaCl in phosphate buffered saline, pH 7.4, with 0.02% sodium azide and 50% glycerol. To ensure its stability, it should be stored at a temperature of -20°C, and it is safe to use for up to 12 months from the date of receipt.
Target
Background	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Tissue specificity	Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Nucleus;
UniPort	P08294