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Rabbit Anti-CD134 Polyclonal Antibody#abs137228

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Description

Catalog-specification	Delivery time	USD price
abs137228-100ug	1-2 Weeks	301.0
abs137228-50ug	1-2 Weeks	201.0

Overview
catalog	abs137228
Other names	The ACT35 antigen, also known as CD134 or OX40, is a cell surface receptor that belongs to the TNF receptor superfamily. This receptor is expressed primarily on activated T cells and plays a crucial role in regulating T cell activation and survival. It binds to OX40 ligand (OX40L), which is found on antigen-presenting cells, and this interaction enhances T cell proliferation and cytokine production. The OX40/OX40L signaling pathway has been implicated in the pathogenesis of autoimmune diseases and cancer. Therefore, targeting OX40 has emerged as a promising strategy for immunotherapy. The TAX transcriptionally-activated glycoprotein 1 receptor has also been identified as a member of the OX40/OX40L signaling pathway. Overall, the OX40 receptor and its ligand represent a key immunomodulatory pathway that is essential for mounting effective immune responses against pathogens and tumors.
Source	Rabbit
Specificity	The endogenous levels of total CD134 can be effectively detected using the CD134 Antibody. To ensure accurate measurement, the antibody recognizes the naturally occurring CD134 protein. This enables researchers to analyze and study the expression of CD134 in various biological samples. By detecting the endogenous CD134 levels, valuable insights can be gained regarding its role and potential implications in different physiological and pathological processes.
Species Reactivity	Human
Antigen	CD134
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CD134.
MW	29 kDa.
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, the product should be kept at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can have a negative impact on its quality. To ensure the longevity and effectiveness of the product, it is recommended to store it in a consistent and controlled environment.
Storage buffer	This rabbit IgG comes in a solution of phosphate buffered saline with a pH level of 7.4, along with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It should be stored at a temperature of -20 °C and has a shelf life of 12 months from the date of receipt.
Target
Background	Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Celluar localization	Plasma Membrane;
UniPort	P43489