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Rabbit Anti-SNIP Polyclonal Antibody#abs135025

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Description

Catalog-specification	Delivery time	USD price
abs135025-100ug	1-2 Weeks	301.0
abs135025-50ug	1-2 Weeks	201.0

Overview
catalog	abs135025
Other names	The p130Cas-associated protein, also known as p140Cap or SNAP-25-interacting protein (SNIP), is a vital component in SRC kinase signaling inhibition. Biologically identified as SRCN1_HUMAN, SRC kinase signaling inhibitor 1, or SRCIN1, this protein regulates cellular functions through its interactions with various proteins and signaling pathways. Its significance in modulating cell growth and differentiation, migration and adhesion, as well as gene expression and ion channel activity, makes it a promising therapeutic target for various diseases. With its versatile roles in cellular processes, p130Cas-associated protein continues to be an exciting subject for scientific study and exploration.
Source	Rabbit
Specificity	The SNIP Antibody can effectively detect the total amount of SNIP that is present naturally within an organism. This means that researchers can rely on this antibody to accurately measure levels of SNIP without having to introduce any foreign materials or substances. By utilizing this method, scientists can gain deeper insights into the specific role that SNIP plays in different biological processes. The high efficacy and specificity of the SNIP Antibody make it a valuable tool for any investigator seeking to unlock the mysteries of this essential protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	SNIP
Application	For Western blotting, a dilution ratio of 1:500-1:1000 is typically recommended. As for immunofluorescence and immunocytochemistry, a ratio of 1:100-1:500 is necessary. When performing ELISA using a peptide as the antigen, a dilution ratio of 1:20000-1:40000 is recommended for optimal results. It is important to carefully follow these dilution recommendations to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	112 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin played a crucial role in the purification of the antiserum through peptide affinity chromatography. By utilizing this resin, the antiserum was able to be thoroughly purified to its highest quality possible.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store the product at a temperature of -20 °C for a duration of one year. It is essential to prevent the occurrence of freeze/thaw cycles repeatedly.
Storage buffer	This product is Rabbit IgG, which is stored in phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C, and it is stable for a period of 12 months from the date of receipt.
Target
Background	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Tissue specificity	Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
Posttranslational modification	Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q9C0H9