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Rabbit Anti-SNF1LK2 Polyclonal Antibody#abs139660

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Description

Catalog-specification	Delivery time	USD price
abs139660-100ug	1-2 Weeks	301.0
abs139660-50ug	1-2 Weeks	201.0

Overview
catalog	abs139660
Other names	SIK2 (Salt Inducible Kinase 2), also known as Qin-induced kinase or Qin induced kinase, belongs to the EC 2.7.11.1 enzyme class. It is encoded by the KIAA0781 gene and is also referred to as LOH11CR1I, QIK, or Salt-inducible protein kinase 2. SIK2 is a serine/threonine protein kinase that plays a crucial role in various cellular processes. It is involved in salt-responsive signaling pathways and is activated in response to high salt concentrations. SIK2 is also implicated in the regulation of energy metabolism and glucose homeostasis. Another name for SIK2 is SNF1 like kinase 2 (SNF1LK2), highlighting its similarity to the SNF1 family of kinases. SNF1 is a serine/threonine protein kinase involved in the regulation of energy metabolism and stress responses in yeast. In summary, SIK2 (Qin-induced kinase) is a salt-inducible serine/threonine protein kinase that is crucial in salt-responsive signaling pathways, energy metabolism, and glucose homeostasis. It shares similarity with the SNF1 family of kinases.
Source	Rabbit
Specificity	The total amount of SNF1LK2 present within an organism can be accurately detected using the SNF1LK2 Antibody. This antibody specifically targets and binds to the endogenous levels of SNF1LK2 in order to provide an accurate measurement.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse;Dog;
Antigen	SNF1LK2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SNF1LK2.
MW	104 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it for a duration of one year at a temperature of -20 °C. It is crucial to avoid subjecting the product to repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Posttranslational modification	Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
Celluar localization	Nucleus;
UniPort	Q9H0K1