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Rabbit Anti-SNCG Polyclonal Antibody#abs136505

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Description

Catalog-specification	Delivery time	USD price
abs136505-100ug	1-2 Weeks	301.0
abs136505-50ug	1-2 Weeks	201.0

Overview
catalog	abs136505
Description	Mutations in this gene have been linked to breast tumor development, as well as its involvement in the pathogenesis of neurodegenerative diseases. This particular gene is a member of the synuclein protein family, known for their association with neurodegenerative disorders.
Other names	The protein known as Breast Cancer Specific Gene 1 (BCSG1) or Breast Cancer Specific Protein 1 (BCSP1) is also referred to as Gamma Synuclein or Gamma-Synuclein. It is alternatively known as Persyn, PRSN, SNCG, SR, Synoretin, Synuclein gamma, and synuclein, gamma (breast cancer-specific protein 1). In humans, it is encoded by the SYUG_HUMAN gene. To create a highly similar content by rearranging the above information while maintaining its original context, we can present it as follows: Breast Cancer Specific Gene 1 (BCSG1), alternatively referred to as Breast Cancer Specific Protein 1 (BCSP1), plays a crucial role in breast cancer progression. It is also known by other names such as Gamma Synuclein or Gamma-Synuclein. Additionally, this protein is recognized as Persyn, PRSN, SNCG, SR, Synoretin, Synuclein gamma, and synuclein, gamma (breast cancer-specific protein 1). In humans, it is encoded by the SYUG_HUMAN gene. Note: The rearranged content maintains the original information but presents it in a slightly different structure and format.
Source	Rabbit
Specificity	The endogenous levels of total SNCG can be detected using the SNCG Antibody. Reordering the content would produce a highly similar statement, conveying the same information in a different manner.
Species Reactivity	Human;Mouse;Rat
Antigen	SNCG
Application	The dilutions for Western Blot (WB) range from 1:500 to 1:2000. For Immunohistochemistry (IHC), the dilutions vary from 1:50 to 1:200. When it comes to Immunofluorescence (IF) or Immunocytochemistry (ICC), the dilutions fall between 1:100 and 1:500. Lastly, for ELISA (peptide), the recommended dilutions are between 1:20000 and 1:40000.
Immunogen	A synthesized peptide derived from human SNCG.
MW	13kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. To ensure the maximum efficiency of the product, it is important to avoid exposing it to repeated cycles of freezing and thawing. Therefore, it is recommended to handle the product with care and to follow the storage instructions provided in order to maintain its quality and effectiveness over time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Tissue specificity	Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Posttranslational modification	Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Celluar localization	Cytoskeleton;Extracellular region or secreted;
UniPort	O76070