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Rabbit Anti-SMRC2 Polyclonal Antibody#abs133665

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Description

Catalog-specification	Delivery time	USD price
abs133665-100ug	1-2 Weeks	301.0
abs133665-50ug	1-2 Weeks	201.0

Overview
catalog	abs133665
Other names	The protein known as BAF170, or BRG1-associated factor 170, is a subunit of the chromatin remodeling complex which plays a crucial role in the regulation of gene expression. Also referred to as CRACC2, Rsc8, or SMARCC2, this protein is a member of the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C. BAF170 participates in a variety of biological processes by modulating the structure and function of chromatin, which ultimately affects gene transcription. Research has shown that mutations in BAF170 have been linked to various diseases, including cancer and developmental disorders. Overall, BAF170 is an essential component of the protein complex which is crucial for the proper functioning of cells in various organisms.
Source	Rabbit
Specificity	The SMRC2 antibody is capable of detecting the total levels of endogenous SMRC2 in biological samples. This antibody binds specifically to SMRC2 and allows for the detection of this protein, which is crucial for understanding its role in various physiological processes. The detection of endogenous SMRC2 is important for research purposes and the SMRC2 antibody provides a specific and reliable tool for such investigations. By utilizing this antibody, researchers can gain insights into the functions and interactions of SMRC2 in different cellular pathways.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse
Antigen	SMRC2
Application	： (WB)，1:500~1:1000。(IF/ICC)，1:100-1:500。(ELISA)，1:20000-1:40000。，，。
Immunogen	A synthesized peptide.
MW	160 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through the process of peptide affinity chromatography. A highly pure form of the antiserum was achieved thanks to this technique.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Tissue specificity	Ubiquitously expressed.
Celluar localization	Nucleus;
UniPort	Q8TAQ2