Phospho-Synapsin (Ser9) Rabbit Polyclonal Antibody#abs130828

abs130828-50ug

1-2 Weeks

201

abs130828-100ug

1-2 Weeks

301

Description

The synapsin gene family includes this particular gene, which encodes for a neuronal phosphoprotein that binds to the cytoplasmic surface of synaptic vesicles. These proteins have common domains and are thought to play a role in synaptogenesis and regulating neurotransmitter release, which could have implications for various neuropsychiatric disorders.

Other names

Synapsin 1, also known as brain protein 4.1, is a crucial protein involved in synaptic transmission. It exists in multiple isoforms, including SYN1, SYN1a, and SYN1b, which are all encoded by the SYN1 gene in humans. These isoforms, such as SYN1_HUMAN, Synapsin-1, and SynapsinI, play essential roles in maintaining proper neuronal function.
Synapsin 1 is responsible for regulating the release of neurotransmitters in synapses, which are the junctions between neurons. It acts by tethering synaptic vesicles, which contain neurotransmitters, to the cytoskeleton of the presynaptic terminal. This tethering allows for the precise distribution and release of neurotransmitters upon neuronal signaling.
Mutations or alterations in Synapsin 1 can lead to impaired synaptic transmission and have been associated with various neurological disorders, including epilepsy and schizophrenia. Studies have shown that mice lacking Synapsin 1 display abnormal behavior and cognitive deficits, highlighting the importance of this protein in normal brain function.
Understanding the function and regulation of Synapsin 1 is crucial in unraveling the complexities of synaptic transmission and its implications in neurological disorders. Further research into this protein and its isoforms may provide valuable insights into the development of novel therapeutic strategies targeting synaptic dysfunction.

Source

Rabbit

Specificity

The Phospho-Synapsin (Ser9) Antibody is designed to specifically recognize and bind to Synapsin protein that is phosphorylated at Serine 9. It is highly sensitive and capable of detecting endogenous levels of phosphorylated Synapsin in samples. However, it does not yield any signal when Synapsin is not phosphorylated at Serine 9. This antibody is useful for studying the phosphorylation status of Synapsin and its role in various cellular processes.

Predictive reaction species

Xenopus;Zebrafish;Pig;Sheep;Rabbit;Bovine;

Application

WB1:500-1:2000，/1:100-1:500，（）1:20000-1:40000。。

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A peptide derived from human Synapsin, specifically around the phosphorylation site of Serine 9, has been synthesized. Is there anything else you would like to know or discuss related to this topic?

Properties

1mg/ml

Purification

The antibody was obtained by purifying rabbit serum using a process involving affinity purification through sequential chromatography on affinity columns for phospho- and non-phospho-peptides. It was carefully crafted to ensure a high level of similarity to the original peptide, guaranteeing its accuracy and effectiveness.

Clonality

Polyclonal Antibody

The recommended storage condition is -20 °C for one year, and it is important to avoid subjecting the product to repeated freeze/thaw cycles.

Storage buffer

The rabbit IgG solution is formulated in a pH 7.4 phosphate buffered saline containing 150mM NaCl, 0.02% sodium azide and 50% glycerol. We highly recommend storing this solution at a temperature of -20°C for stability purposes. Please note that this solution will remain stable for up to 12 months from the date of receipt.

Target

Background

A neural protein that covers synaptic vesicles, interacts with the cytoskeleton, and is thought to play a role in the regulation of neurotransmitter release is known as a neuronal phosphoprotein. It is essential for the specific nitric-oxide-related processes that occur in presynaptic regions when combined with NOS1 and CAPON proteins.

Celluar localization

Cytosol;Golgi apparatus;Nucleus;

P17600