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Rabbit Anti-SLC5A3 Polyclonal Antibody#abs134823

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Description

Catalog-specification	Delivery time	USD price
abs134823-100ug	1-2 Weeks	301.0
abs134823-50ug	1-2 Weeks	201.0

Overview
catalog	abs134823
Other names	The Na(+)/myo-inositol cotransporter, also known as SLC5A3 or SMIT2, is a protein that belongs to the solute carrier family 5 (inositol transporters), member 3. This transporter is responsible for the transport of myo-inositol and sodium ions across cell membranes. The sodium/myo inositol cotransporter 1 plays an important role in balancing the level of myo-inositol within cells, which is a key component of many cellular processes and functions. The transport of myo-inositol into cells is essential for its utilization in various metabolic pathways, including signal transduction, lipid metabolism, and osmoregulation. The Na(+)/myo inositol cotransporter is widely expressed in many tissues throughout the body, including the brain, liver, kidney, and intestine. Its dysfunction has been linked to various diseases, such as diabetes, obesity, and neurodegenerative disorders. Understanding the function and regulation of the sodium/myo inositol cotransporter is important for developing therapeutics targeting these diseases. Researchers continue to investigate the role of this transporter in cellular processes and its potential as a target for drug development.
Source	Rabbit
Specificity	The total SLC5A3 levels can be accurately identified using the SLC5A3 Antibody, which specifically detects endogenous amounts of the protein. To ensure reliable results, it is essential to use an antibody that targets the total SLC5A3 protein. This allows for precise detection and analysis of the endogenous levels of SLC5A3.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	SLC5A3
Application	For Western Blot analysis, a dilution of 1:500 to 1:1000 is recommended. When it comes to IF/ICC (Immunofluorescence/Immunocytochemistry), a dilution range of 1:100 to 1:500 is ideal. For ELISA using peptide, a dilution of 1:20000 to 1:40000 is suggested for optimal results. It is important to closely follow these dilution guidelines for accurate and consistent experimental outcomes.
Immunogen	A synthesized peptide.
MW	80 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	This is a formulation of Rabbit IgG in phosphate buffered saline (pH 7.4) with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and can be stored for up to 12 months from the date of receipt.
Target
Background	Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.
Celluar localization	Plasma Membrane;
UniPort	P53794