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Rabbit Anti-SENP5 Polyclonal Antibody #abs130212

Please note that the price mentioned here is only for your reference. For detailed pricing information, we recommend you to get in touch with our seller Vecent. Data Examples Western blot analysis on COS7 cell lysate using SENP5 Antibody This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs130212-50ug	1-2 Weeks	201
abs130212-100ug	1-2 Weeks	301

Please note that the price mentioned here is only for your reference. For detailed pricing information, we recommend you to get in touch with our seller Vecent.

Overview
Description	This protease, known as SENP5, plays a vital role in the SUMO pathway as it facilitates two crucial functions. Firstly, it is responsible for processing full-length SUMO3, converting it into its mature and functional form. Additionally, SENP5 also aids in the deconjugation process of SUMO2 and SUMO3 from specific target proteins. However, it is worth noting that SENP5 exhibits relatively weaker proteolytic activity when it comes to full-length SUMO1 or SUMO1 conjugates. Overall, SENP5's multifunctional role highlights its significance in regulating and maintaining the integrity of the SUMO pathway.
Other names	FKSG45 is a protease also known as SENP5. It is encoded by the FLJ42398 gene and belongs to the MGC27076 protein family. SENP5, or Sentrin-specific protease 5, is a specific peptidase that targets Sentrin and SUMO proteins. It is primarily involved in the regulation of protein modification processes. SENP5_HUMAN, or Sentrin/SUMO-specific protease SENP5, is the human version of this protease. It plays a vital role in cleaving SUMO peptides and mediating SUMO-dependent signaling pathways. SUMO1/sentrin specific peptidase 5 is another name for SENP5, indicating its substrate specificity towards SUMO1 and Sentrin proteins. Overall, SENP5 is an important enzyme that contributes to the regulation of protein function and cellular processes through its protease activity.
Source	Rabbit
Specificity	The antibody for SENP5 can be used to detect the total endogenous levels of this protein. This means that the antibody is capable of recognizing all the different forms that SENP5 can take within a cell. With this information, researchers can study the role of SENP5 in various biological processes and better understand its function.
Species Reactivity	Human;Mouse;Monkey
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Application	For Western blot, the recommended dilution range is 1:500 to 1:3000. When it comes to using this antibody for immunohistochemistry, the recommended dilution range is 1:50 to 1:200. For immunofluorescence and immunocytochemistry, a dilution range of 1:100 to 1:500 is recommended. If you are planning to use this antibody for ELISA with a peptide antigen, the recommended dilution range is between 1:20000 and 1:40000. It is important to note these dilution ranges in order to ensure that you are using the antibody correctly for your experiments.
Immunogen	A synthesized peptide derived from human SENP5.
Properties
Concentration	1mg/ml
Purification	The purification of the antiserum involved the use of SulfoLink™ Coupling Resin for peptide affinity chromatography. This specialized process effectively removed impurities, resulting in a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store the item at a temperature of -20 °C for a duration of one year. It is crucial to prevent any instances of repeatedly freezing and thawing the item during this period.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in phosphate buffered saline at pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the product is guaranteed for a period of 12 months from the date of receipt.
Target
Background	This protease serves two vital functions in the SUMO pathway by processing full-length SUMO3 into its mature form and removing SUMO2 and SUMO3 from targeted proteins. It possesses limited proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Its presence is essential for the proper functioning of cell division. Reorganizing and modifying the original text information, this protease plays a significant role in the proper functioning of the SUMO pathway. Its critical functions include processing full-length SUMO3, removing SUMO2 and SUMO3 from targeted proteins, and also shows weak proteolytic activity against SUMO1. It plays a crucial role in cell division and is required for its proper functioning.
Celluar localization	Nucleus;
UniPort	Q96HI0