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Rabbit Anti-ITBP1 Polyclonal Antibody#abs132925

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Description

Catalog-specification	Delivery time	USD price
abs132925-100ug	1-2 Weeks	301.0
abs132925-50ug	1-2 Weeks	201.0

Overview
catalog	abs132925
Other names	ICAP1 (Integrin cytoplasmic domain associated protein 1), also known as Bodenin or Integrin beta 1 binding protein 1, is a protein that plays a crucial role in binding to Integrin beta-1 and regulating cellular processes. It exists in different isoforms, including ICAP 1A, ICAP 1alpha, ICAP 1B, and ICAP-1. ICAP1 is involved in various cellular functions and is essential for maintaining the integrity of cell adhesion and signaling pathways. It acts as a mediator between integrins and intracellular signaling molecules, contributing to cell adhesion, migration, and cytoskeletal organization. The importance of ICAP1 in cellular processes emphasizes its potential as a therapeutic target for various diseases. In summary, ICAP1 is a multifunctional protein that regulates integrin-mediated cellular functions and serves as a key player in maintaining cellular homeostasis.
Source	Rabbit
Specificity	The ITBP1 antibody is capable of detecting the complete amount of ITBP1 present within the system, including the endogenous levels. The content can be rephrased by ensuring the information presented remains reliable to the original text.
Species Reactivity	Human;Mouse
Predictive reaction species	Horse;Dog;
Antigen	ITBP1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was purified via peptide affinity chromatography. In order to ensure the highest quality product, this method was used to refine the antiserum to its optimal state.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and efficacy of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing as this can affect its stability. It is advisable to adhere to the recommended storage conditions to ensure that the product remains suitable for use.
Storage buffer	In a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide, rabbit IgG is present. Additionally, the solution contains 50% glycerol for stabilization.
Target
Background	Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.
Tissue specificity	Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate.
Posttranslational modification	Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	O14713