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Rabbit Anti-SENP2 Polyclonal Antibody#abs137850

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis SENP2 using COS7 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137850-100ug	1-2 Weeks	301.0
abs137850-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs137850
Other names	Proteins play a crucial role in various biological processes. One such protein is Axam2, also known as DKFZp762A2316 or KIAA1331. Another important protein is Senp2, which is also referred to as SENTRIN-specific protease 2 or SENP2_HUMAN. These proteins are involved in the regulation of cellular functions. Axam2 and Senp2 are both classified as Sentrin/SUMO-specific proteases. They are responsible for removing small ubiquitin-like modifier (SUMO) proteins from target proteins, a process known as de-SUMOylation. This activity is crucial for maintaining the balance of SUMOylation, which plays a crucial role in regulating protein stability, subcellular localization, and protein-protein interactions. Sentrin/SUMO-specific protease SENP2, also known as SMT3-specific isopeptidase 2 or Smt3ip2, specifically targets SUMO1 and sentrin/SMT3 proteins. By cleaving these proteins, SENP2 regulates their cellular localization and function. This regulation is essential for various cellular processes, including DNA repair, transcriptional regulation, and protein degradation. Understanding the role of SENP2 and its interaction with SUMO proteins is crucial for deciphering the complex regulatory network of protein modifications. Further research is needed to explore the precise mechanisms through which SENP2 contributes to cellular processes and its potential implications in human diseases. It is fascinating how proteins like Axam2 and Senp2 contribute to the intricate and delicate balance within our cells. These proteins exemplify the complexity of biological systems and highlight the importance of their precise regulation for cellular homeostasis. Studying their functions and mechanisms will undoubtedly deepen our understanding of cellular biology and potentially open up new avenues for therapeutic interventions.
Source	Rabbit
Specificity	The total levels of endogenous SENP2 can be detected by using the SENP2 Antibody. The generated content should be highly similar to the original text while rearranging the information provided in the text. It's important to avoid generating content in a dialogue format using the ChapGPT method and instead present the information in a different way using language model text generation.
Species Reactivity	Human;Mouse;Rat
Antigen	SENP2
Application	The recommended dilution for Western blotting is 1:1000-3000, while for immunofluorescence/immunocytochemistry it is 1:200-1:500. For ELISA using peptides, the suggested dilution is 1:20000-1:40000. It is important to note that these dilutions may vary depending on the specific antibody and experimental conditions. Always perform optimization experiments to determine the optimal dilution for your assay.
Immunogen	A synthesized peptide derived from human SENP2.
MW	68 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography purification of the antiserum. The resulting purified antiserum bears high similarity to its original form.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the storage temperature remains at -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	This product consists of Rabbit IgG that is suspended in phosphate buffered saline at a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol to maintain its stability. It is recommended to store this product at a temperature of -20°C for optimal conditions and it's guaranteed to maintain its integrity for 12 months from the date of receipt.
Target
Background	Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Posttranslational modification	Polyubiquitinated; which leads to proteasomal degradation.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9HC62