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Rabbit Anti-TNFSF13 Polyclonal Antibody#abs135889

Description

Catalog-specification	Delivery time	USD price
abs135889-100ug	1-2 Weeks	301.0
abs135889-50ug	1-2 Weeks	201.0

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Overview
catalog	abs135889
Description	BAFF (B-cell Activating Factor), a protein belonging to the TNF superfamily, is a transmembrane protein that exists as a homotrimer (1). It can be cleaved to produce a soluble cytokine. Additionally, BAFF has the ability to further assemble into structures known as 60-mers (1). Various immune cells including neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells express BAFF (1,2). The primary functions of BAFF revolve around B cell development, survival, and activation (1,3,4). BAFF interacts with three different receptors called BAFF-R, TACI, and BCMA (1). The expression of these receptors differs during B cell development and among different subsets of B cells (1,2,4). While both BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI specifically binds to BAFF that is either membrane-bound or in higher order structures (1). The interaction between BAFF and its receptors, particularly BAFF-R, triggers various signaling pathways such as the canonical and non-canonical NF-κB pathways, PI3K/Akt, and mTOR (2,4). The non-canonical NF-κB pathway activation through BAFF-R is controlled negatively by a protein called TRAF3 (5). Increased levels of BAFF have been associated with the exacerbation of autoimmune disorders, making BAFF an attractive target for therapeutic interventions (2).
Other names	APRIL, also known as a proliferation-inducing ligand or CD256, is a protein that belongs to the tumor necrosis factor superfamily. It is involved in several biological processes such as cell proliferation, differentiation, and survival. Other names for APRIL include TALL-2, TALL2, and TNF-related death ligand. Furthermore, APRIL is also known as TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TNFSF13, TRDL-1, TRDL1, and ZTNF2. This protein plays a crucial role in the regulation of immune response and has been associated with various autoimmune diseases and cancers. Researchers have targeted APRIL as a potential therapeutic target for the treatment of these diseases. Overall, APRIL is a complex protein with important functions in the body.
Source	Rabbit
Specificity	The detection of total TNFSF13 at endogenous levels is facilitated by the TNFSF13 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	TNFSF13
Application	The dilution range for WB is 1:500 to 1:2000, while for IHC it is 1:50 to 1:200. For IF/ICC, the recommended dilution is 1:100-1:500. When it comes to ELISA using a peptide as the antigen, a dilution range of 1:20000 to 1:40000 is suggested. It is important to follow these dilution ratios for optimal results in your experiments.
Immunogen	A synthesized peptide derived from human TNFSF13.
MW	27kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Tissue specificity	Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Posttranslational modification	The precursor is cleaved by furin.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	O75888