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Rabbit Anti-Rsk-3 Polyclonal Antibody#abs138123

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Description

Catalog-specification	Delivery time	USD price
abs138123-100ug	1-2 Weeks	301.0
abs138123-50ug	1-2 Weeks	201.0

Overview
catalog	abs138123
Other names	MAP kinase-activated protein kinase 1c, also known as p90RSK2 or RSK-3, is a 90 kDa ribosomal protein S6 kinase involved in cellular signaling pathways. It plays a crucial role in mitogen-activated protein kinase (MAPK) signaling and is activated by MAP kinase activation. This protein kinase is encoded by the RPS6KA2 gene in humans and is categorized as S6K alpha-2. It is an essential component in the regulation of cellular processes and is known to phosphorylate numerous substrates, including transcription factors and other kinases. The diverse functions of p90RSK2 make it a key player in various cellular events, such as cell growth, differentiation, and survival.
Source	Rabbit
Specificity	The Rsk-3 Antibody has the ability to identify total Rsk-3 at levels that are present within the body. This means that the endogenous levels of Rsk-3 can be effectively detected using this antibody. In order to convey this information in a similar yet unique way, one could say: The Rsk-3 Antibody is effective in detecting total Rsk-3 within the body at its natural levels. This means that endogenous levels of Rsk-3 can be accurately identified using this antibody.
Species Reactivity	Human;Mouse
Antigen	Rsk-3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Rsk-3.
MW	83 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, which can impact its efficacy.
Storage buffer	This rabbit IgG is stored in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and remains stable for 12 months from the date of receipt.
Target
Background	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Tissue specificity	Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Posttranslational modification	Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Celluar localization	Cytosol;Nucleus;
UniPort	Q15349