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Rabbit Anti-TSEN54 Polyclonal Antibody#abs134883

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Description

Catalog-specification	Delivery time	USD price
abs134883-100ug	1-2 Weeks	301.0
abs134883-50ug	1-2 Weeks	201.0

Overview
catalog	abs134883
Other names	The TSEN54 gene, also known as HsSen54 or PCH2A, encodes a protein referred to as SEN54. This protein plays a crucial role as a subunit of tRNA-splicing endonuclease, which is responsible for the removal of introns from transfer RNA molecules. SEN54 is considered a homolog of the SEN54L protein in humans. Its function is vital in the process of tRNA splicing, ensuring the proper maturation of tRNA molecules. The alternative names for SEN54 include PCH4 and Tsen54.
Source	Rabbit
Specificity	The total TSEN54 present in the body can be accurately detected using the TSEN54 Antibody. This antibody specifically targets the endogenous levels of TSEN54 protein, which allows for the reliable identification and quantification of this protein in biological samples. By utilizing the TSEN54 Antibody, researchers can study the role and function of TSEN54 in various cellular processes and pathological conditions. Its high specificity and sensitivity make it a valuable tool for understanding the biological significance of TSEN54.
Species Reactivity	Human;Mouse
Antigen	TSEN54
Application	For WB, the recommended dilution range is 1:500 to 1:1000. When it comes to IHC, the suggested dilution range is 1:50 to 1:200. In the case of IF/ICC, it is advisable to dilute the sample at a range of 1:100 to 1:500. Lastly, when performing ELISA with a peptide, the recommended dilution range is 1:20000 to 1:40000. Please note that this generated content is based on the original text information.
Immunogen	A synthesized peptide.
MW	59 KD
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage conditions for this product include keeping it at a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to repeated cycles of freezing and thawing.
Storage buffer	This solution contains rabbit IgG dissolved in phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C, and it remains stable for a period of 12 months from the date of receipt.
Target
Background	Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Celluar localization	Nucleus;
UniPort	Q7Z6J9