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Rabbit Anti-RPAP2 Polyclonal Antibody#abs134747

Description

Catalog-specification	Delivery time	USD price
abs134747-100ug	1-2 Weeks	301.0
abs134747-50ug	1-2 Weeks	201.0

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Overview
catalog	abs134747
Other names	RPAP2, also known as RNA polymerase II-associated protein 2, is a putative phosphatase subunit B1 CTD of RNA polymerase II. It plays a crucial role in the regulation of gene expression by dephosphorylating the C-terminal domain (CTD) of RNA polymerase II. RPAP2 is a human protein that is involved in various biological processes associated with transcription. Its function is to modulate the activity of RNA polymerase II, thereby influencing the transcriptional machinery. With its integral role in gene expression, RPAP2 is an essential component of cellular processes and warrants further investigation.
Source	Rabbit
Specificity	The RPAP2 Antibody is capable of detecting the total levels of endogenous RPAP2 protein. This means that it can precisely detect the amount of RPAP2 protein present within a biological sample. If you need to conduct any research or experiments that require accurate measurement of RPAP2 protein, this antibody may be a valuable tool to have on hand.
Species Reactivity	Human
Antigen	RPAP2
Application	For Western Blotting, the recommended dilution range is between 1:500 to 1:1000, while for Immunofluorescence/Immunocytochemistry, the dilution range is between 1:100 to 1:500. For ELISA using a peptide as the antigen, the recommended dilution range is between 1:20000 to 1:40000. It is important to follow the recommended dilution ranges to achieve optimal results in your experiments.
Immunogen	A synthesized peptide.
MW	70 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. The resulting product is highly purified and suitable for research and medical applications.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it at a temperature of -20 °C for a period of one year. It is important to avoid exposing it to repeated cycles of freezing and thawing. By following these storage guidelines, you can ensure that the product remains effective and suitable for your needs over an extended period of time.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, along with 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, and it has a shelf life of 12 months from the date of receipt. Please note that this information is based on the original text and is intended to provide a similar description of the product.
Target
Background	This protein phosphatase performs CTD phosphatase activity and exerts control over the transcription of snRNA genes. Its function involves recognition and binding to phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) found in the largest subunit of RNA polymerase II known as POLR2A. Through its action, it facilitates the dephosphorylation of 'Ser-5' of the CTD, ultimately leading to the promotion of snRNA gene transcription. An alternative representation of this information could be: A protein phosphatase exhibiting CTD phosphatase activity regulates the transcription of snRNA genes. Its primary role is the identification and binding of the phosphorylated 'Ser-7' residue located within the C-terminal heptapeptide repeat domain (CTD) of POLR2A, the largest subunit of RNA polymerase II. Consequently, it catalyzes the dephosphorylation of 'Ser-5' within the CTD, ultimately facilitating the transcriptional activation of snRNA genes.
Celluar localization	Cytosol;Nucleus;
UniPort	Q8IXW5