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Rabbit Anti-UIMC1 Polyclonal Antibody#abs137741

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Description

Catalog-specification	Delivery time	USD price
abs137741-100ug	1-2 Weeks	301.0
abs137741-50ug	1-2 Weeks	201.0

Overview
catalog	abs137741
Other names	The nuclear zinc finger protein known as RAP80 is an important subunit of the BRCA1-A complex. This receptor-associated protein 80 is also referred to as ubiquitin interaction motif containing protein 1, or UIMC1. Another name for this protein is retinoid x receptor interacting protein 110, or RIP110. The X2HRIP110, Rxrip110, and OTTHUMP codes are also associated with RAP80. The protein is characterized by its ubiquitin interaction motif, which allows it to bind to and interact with ubiquitin molecules. Through this interaction, RAP80 is involved in the regulation of DNA repair and the maintenance of genomic stability.
Source	Rabbit
Specificity	The UIMC1 Antibody is capable of detecting the total endogenous levels of UIMC1. This means that the antibody can accurately identify UIMC1 in its entirety, regardless of any potential modifications or variations. It is important to note that this antibody is specific to UIMC1 and will not detect other proteins or molecules. With its precise detection capabilities, the UIMC1 Antibody is a valuable tool for researchers studying UIMC1 and its biological functions.
Species Reactivity	Human
Predictive reaction species	Rabbit;Dog;Horse
Antigen	UIMC1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human UIMC1.
MW	80 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. A highly similar content can be generated by rephrasing the above information, while ensuring that the context remains intact.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref. 37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Tissue specificity	Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.
Posttranslational modification	Sumoylated.Phosphorylated upon DNA damage by ATM or ATR.
Celluar localization	Nucleus;
UniPort	Q96RL1