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Rabbit Anti-IL1F7 Polyclonal Antibody#abs139632

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Description

Catalog-specification	Delivery time	USD price
abs139632-100ug	1-2 Weeks	301.0
abs139632-50ug	1-2 Weeks	201.0

Overview
catalog	abs139632
Other names	There are a variety of names that are associated with Interleukin-1 family member 7, including FIL1, FIL1 zeta, FIL1(ZETA), FIL1Z, IL-1 zeta, IL-1F7, IL-1F7b (also known as IL-1H4, IL-1H, IL-1RP1), IL-1H4, IL-1RP1, IL-1X, IL-1X protein, IL-1 zeta, IL-1F7, IL-1H, IL-1H4, IL-1RP1, and IL-1X. These all refer to the same protein, which is involved in the immune response and inflammation. Another name associated with this protein is IL-37. It is a member of the interleukin-1 superfamily and is closely related to interleukin-1 homolog 4 and interleukin-1-related protein. Together, these proteins play an important role in the regulation of immune and inflammatory responses, as well as in the development of various diseases related to inflammation. Overall, there is a lot of interest in understanding the function of these interleukin-1 family members and their potential as therapeutic targets for immune-related disorders.
Source	Rabbit
Specificity	The IL1F7 Antibody is designed to recognize the total IL1F7 protein levels that occur naturally within the body. This means that it has the capability to detect the endogenous levels of IL1F7, without requiring any external introduction of the protein. By utilizing this antibody, researchers are able to gain a greater understanding of IL1F7's functions and behaviors within the body.
Species Reactivity	Human
Antigen	IL1F7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IL1F7.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum. A procedure was carried out in which the antiserum was subjected to purification using this resin affinity chromatography technique.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage is recommended at -20 °C. It is important to prevent the product from undergoing repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Tissue specificity	In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Posttranslational modification	Proteolytically converted to the mature form by CASP1.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	Q9NZH6