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Rabbit Anti-RNUXA Polyclonal Antibody#abs134748

Description

Catalog-specification	Delivery time	USD price
abs134748-100ug	1-2 Weeks	301.0
abs134748-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For more detailed pricing information, kindly get in touch with our seller, Vecent. It is important to emphasize that the generated content should be based on the original text information by rearranging the wording and not relying on ChapGPT's content generation method. Let us communicate in a way that is vastly different from ChapGPT's text generation technique.

Overview
catalog	abs134748
Other names	RNUXA is an abbreviation for RNA U, small nuclear RNA export adapter protein, also known as phosphorylated adapter RNA export protein or PHAX. This protein acts as a phosphorylated adaptor for RNA export. It plays a crucial role in facilitating the transportation of small nuclear RNA (snRNA) from the nucleus to the cytoplasm. This process is vital for the proper functioning of RNA in various cellular processes. The phosphorylated adapter RNA export protein interacts with the snRNA molecules and assists in their export through nuclear pores. It ensures that the snRNA molecules reach their designated cytoplasmic compartments where they participate in essential RNA processing events. The phosphorylation of this adapter protein regulates its functionality in RNA export, adding an additional layer of control to the process. Understanding the function and regulation of PHAX, or RNUXA, is crucial for unraveling the mechanisms that govern the flow of genetic information within cells. Further research on this protein can provide valuable insights into RNA export and its significance in cellular homeostasis and disease development.
Source	Rabbit
Specificity	The RNUXA Antibody is capable of recognizing the entire quantity of endogenous RNUXA. A closely resembling content can be written by reorganizing the original text's information, guaranteeing to maintain accuracy.
Species Reactivity	Human
Predictive reaction species	Horse;Dog;
Antigen	RNUXA
Application	For Western Blotting, a dilution ratio of 1:500 to 1:1000 is recommended. The recommended dilution range for Immunofluorescence/Immunocytochemistry is between 1:100 to 1:500. When it comes to ELISA using peptide, the ideal dilution ratio is between 1:20000 to 1:40000. It's crucial to follow these dilution guidelines to obtain accurate and reproducible results.
Immunogen	A synthesized peptide.
MW	48 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to keep the product stored at -20 °C for a year without undergoing repeated freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG include storing it at -20 °C in phosphate buffered saline (pH 7.4) with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it under these conditions for up to 12 months from the date of receipt.
Target
Background	A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Posttranslational modification	Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm (By similarity).
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q9H814

This product is for research use only, not for use in diagnostic prodecures or in human.

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