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Rabbit Anti-LGALS8 Polyclonal Antibody#abs137739

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Description

Catalog-specification	Delivery time	USD price
abs137739-100ug	1-2 Weeks	301.0
abs137739-50ug	1-2 Weeks	201.0

Overview
catalog	abs137739
Other names	Gal-8, also known as Galectin-8, LGAL S8, or PCTA-1, is a lectin protein that binds to galactoside-containing molecules. It is encoded by the LGALS8 gene in humans. Gal-8 has been shown to have various roles in cellular processes such as cell adhesion, apoptosis, and inflammation. Po66 carbohydrate-binding protein, also known as Po66 CBP, is another name for Gal-8. It is called Prostate carcinoma tumor antigen 1 because it is overexpressed in prostate cancer. Gal-8 is a soluble protein that can be found both intracellularly and extracellularly. It is involved in modulating the immune response and has been implicated in various pathologies such as cancer, viral infections, and autoimmune diseases. Gal-8 has also been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. Overall, Gal-8 is a multifunctional protein with diverse roles in cellular and physiological processes.
Source	Rabbit
Specificity	The LGALS8 Antibody is designed to specifically detect the total LGALS8 present in the body at its natural levels. It is capable of identifying the endogenous levels of LGALS8, allowing researchers to accurately study its functions and properties.
Species Reactivity	Human;Mouse
Antigen	LGALS8
Application	The recommended dilutions for western blotting are 1:1000-3000, while for immunofluorescence and immunocytochemistry, it is 1:100-1:500. For ELISA using peptide, the suggested dilution ranges from 1:20000-1:40000. Please keep in mind that the statement above has been rearranged to present the information in a different manner than the original text.
Immunogen	A synthesized peptide derived from human LGALS8.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was conducted through peptide affinity chromatography. A highly efficient process was employed to ensure that the resulting product was purified to a high degree. This methodology utilized advanced techniques to provide the necessary affinity for the specific peptide. Through this process, the antiserum was able to be purified to meet the required standards.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and effectiveness of the product, it is recommended to store it at a temperature of -20 °C for a year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. This will help ensure that the product remains stable and usable for the intended purpose.
Storage buffer	This product is Rabbit IgG in phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C. The product is stable for 12 months from the date of receipt.
Target
Background	Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).
Tissue specificity	Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	O00214