Phospho-PPAR Alpha (Ser21) Rabbit Polyclonal Antibody#abs139883
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Description
| Catalog-specification | Delivery time | USD price |
abs139883-100ug | 1-2 Weeks | 301.0 |
abs139883-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference. If you are interested in getting the detailed pricing for our products, please feel free to contact our seller, Vecent. He will be more than happy to assist you in this regard. Moreover, we would like to emphasize that the content generated by our language model may differ significantly from the original text. Therefore, we recommend using a different approach to generate a highly similar content.
| Overview | |
catalog | abs139883 |
| Other names | Nuclear receptor subfamily 1 group C member 1, also known as PPAR-alpha or Peroxisome proliferative activated receptor alpha, is a protein encoded by the PPAR gene. Other aliases for this protein include MGC2237 and MGC2452. PPAR-alpha is a transcription factor that plays a key role in regulating lipid metabolism and glucose homeostasis. It is predominantly expressed in tissues with high metabolic activity, such as the liver, skeletal muscle, and heart. Activation of PPAR-alpha results in the upregulation of genes involved in lipid uptake, metabolism, and transport. This leads to increased beta-oxidation of fatty acids and a decrease in triglyceride and cholesterol levels. In addition to its metabolic functions, PPAR-alpha is also involved in inflammation and cell differentiation. Its role in these processes is mediated through its ability to regulate the expression of various cytokines and growth factors. Overall, PPAR-alpha is a crucial regulator of metabolic and inflammatory processes in the body. Its dysregulation is associated with a variety of diseases, including dyslipidemia, diabetes, and cardiovascular disease. |
| Source | Rabbit |
| Specificity | The antibody named PPAR α (Phospho-Ser21) specifically identifies PPAR α protein that carries a phosphorylation modification at the Ser21 site. It has the ability to detect endogenous levels of PPAR α only when this phosphorylation event occurs at Ser21. By recognizing this specific modification, the antibody allows for the identification and analysis of PPAR α phosphorylation at the Ser21 residue. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | PPAR alpha |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | Based on the original text information, a highly similar content can be generated by rearranging the sentences. Please note that the content generated is not a dialogue but a different way of presenting information. Phospho-Ser21 is a human PPAR α derived peptide that has been synthesized. The synthesis process involves deriving the peptide from human PPAR α and phosphorylating the Serine amino acid at position 21. This modification is important as it plays a crucial role in the function of PPAR α. PPAR α, also known as Peroxisome proliferator-activated receptor alpha, is a transcription factor involved in lipid metabolism and energy homeostasis. It binds to specific DNA sequences and regulates the expression of target genes. The phosphorylation of Serine 21 in PPAR α is associated with the activation of its transcriptional activity. The synthesized peptide derived from human PPAR α, specifically targeting the phosphorylated Serine 21, can be used for various research purposes. It can aid in studying the role of PPAR α in lipid metabolism, energy regulation, and related diseases such as metabolic disorders and cardiovascular diseases. Moreover, this synthesized peptide can be utilized in drug discovery and development studies. By understanding the function and regulation of PPAR α, novel therapeutic strategies can be developed to modulate its activity and potentially treat metabolic disorders. In conclusion, the synthesis of a peptide derived from human PPAR α with phosphorylated Serine 21 provides researchers with a valuable tool to investigate the function, regulation, and potential therapeutic applications of this important transcription factor involved in lipid metabolism and energy homeostasis. |
| MW | 52 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The affinity-purified antibody was obtained from rabbit serum that underwent sequential chromatography on phospho- and non-phospho-peptide affinity columns. The purification process involved purifying the antibody using these specific columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | /，20°C。 |
| Storage buffer | This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It must be stored at -20 °C for optimal stability, and it can be safely kept for up to 12 months from the date of receipt. Please handle with care to ensure maximum efficacy and longevity of this product. |
Target | |
Background | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
| Tissue specificity | Skeletal muscle, liver, heart and kidney. |
| Celluar localization | Nucleus; |
| UniPort | Q07869 |
Western blot analysis PPAR α (Phospho-Ser21) using K562 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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