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Rabbit Anti-ROR2 Polyclonal Antibody#abs137383

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Description

Catalog-specification	Delivery time	USD price
abs137383-100ug	1-2 Weeks	301.0
abs137383-50ug	1-2 Weeks	201.0

Overview
catalog	abs137383
Other names	ROR2, also known as Brachydactyly type B or receptor-related 2, is a neurotrophic tyrosine kinase that belongs to the receptor tyrosine kinase-like orphan receptor 2 family. Encoded by MGC163394, this transmembrane receptor plays a crucial role in cellular signaling pathways. With EC 2.7.10.1 as its assigned Enzyme Commission number, ROR2 is involved in various biological processes. Neurotrophic tyrosine kinase, receptor-related 2, or NTRKR2, is a highly similar protein to ROR2. Both proteins share a common tyrosine-protein kinase transmembrane receptor domain. Their structural similarities suggest that they may have overlapping functions in cellular communication. Research on ROR2 and NTRKR2 has revealed their involvement in developmental disorders like Brachydactyly type B, which is characterized by short fingers and toes. The identification of the ROR2_HUMAN gene has provided valuable insights into the pathogenesis of Brachydactyly type B. Understanding the mechanisms underlying this disorder may lead to potential therapeutic interventions. In conclusion, ROR2 and NTRKR2 are closely related proteins that play important roles in cellular signaling and development. Their association with Brachydactyly type B highlights the significance of these neurotrophic tyrosine kinases in human health and disease.
Source	Rabbit
Specificity	The ROR2 Antibody is designed to specifically identify and measure the levels of total ROR2 protein present in cells and tissues. It enables the detection of endogenous levels of ROR2, providing valuable information about its expression in biological samples. The antibody-based approach allows for accurate and reliable quantification of ROR2, aiding in the understanding of its role in various physiological and pathological processes.
Species Reactivity	Human;Mouse
Antigen	ROR2
Application	The recommended dilution range for western blot is 1:1000-3000, while for IF/ICC it is 1:200-1:500. For ELISA using peptide, the suggested dilution is 1:20000-1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human ROR2.
MW	105kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. The resulting product was highly purified and ready for use in further applications.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the item at -20 °C for a duration of one year, while avoiding any instances of repeated freeze and thaw cycles.
Storage buffer	This product contains rabbit IgG in a buffer solution of phosphate, saline, and sodium azide. The pH is maintained at 7.4, and the NaCl concentration is 150mM. The solution also contains 50% glycerol as a stabilizer. It is recommended to store this product at -20 °C for optimal stability. It should remain stable for up to 12 months from the date of receipt.
Target
Background	Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).
Tissue specificity	Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q01974