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Rabbit Anti-RNLS Polyclonal Antibody#abs137606

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Description

Catalog-specification	Delivery time	USD price
abs137606-100ug	1-2 Weeks	301.0
abs137606-50ug	1-2 Weeks	201.0

Overview
catalog	abs137606
Other names	HGNC: 25641; MAO C; Renalase FAD dependent amine oxidase; Chromosome 10 open reading frame 59; RNLS_HUMAN; FLJ11218; Monoamine oxidase-C; AI452315; Hypothetical protein LOC55328; mMAO C; C10orf59; AW060440; RNLS. 6530404N21Rik. I have rearranged the given text to provide a different order and presentation of the information while still maintaining the original content.
Source	Rabbit
Specificity	The total RNLS protein can be detected using the RNLS antibody, which is designed to specifically bind to the endogenous levels of RNLS.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Horse;
Antigen	RNLS
Application	The suggested dilutions for Western blotting (WB) range from 1:1000 to 1:3000, while for immunohistochemistry (IHC) it is recommended to use a dilution of 1:200. When performing ELISA with a peptide, the optimal dilution is between 1:20000 and 1:40000. It is important to consider these dilution factors when conducting experiments to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human RNLS.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. A highly effective method, this process ensures that the resulting product is highly refined and free from any impurities that may interfere with its intended use. Overall, the use of peptide affinity chromatography is essential in the production of high-quality antiserum for research and therapeutic applications.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure long-term storage, it is recommended that the product be stored at a temperature of -20 °C for up to a year. It is important to avoid repeated freezing and thawing cycles, as this can impact the quality and effectiveness of the product. So always exercise caution when storing the product and don't let it go through temperature fluctuations.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and remains stable for 12 months from the date of receipt.
Target
Background	Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Tissue specificity	Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
Celluar localization	Extracellular region or secreted;
UniPort	Q5VYX0