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Rabbit Anti-UGT2B Polyclonal Antibody#abs137211

Please note that the price mentioned above is only for your reference. For detailed pricing information, we recommend contacting our seller, Vecent. Western blot analysis UGT2B using HepG2 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137211-100ug	1-2 Weeks	301.0
abs137211-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we recommend contacting our seller, Vecent.

Overview
catalog	abs137211
Other names	UDP glucuronosyltransferase 2B17, also known as C19 steroid specific UDPGT or UDB17, is an enzyme involved in the glucuronidation process of C19 steroids. It plays a crucial role in metabolizing these steroids by transferring a glucuronosyl group to their molecules. The activity of UDPGT 2B17 ensures the detoxification and elimination of C19 steroids from the body. Understanding the function and regulation of this enzyme is essential in studying the metabolism and effects of C19 steroids in various physiological and pathological conditions.
Source	Rabbit
Specificity	The antibody UGT2B is capable of specifically identifying and quantifying the total levels of endogenous UGT2B protein.
Species Reactivity	Human;Mouse
Antigen	UGT2B
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human UGT2B.
MW	61 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To ensure maximum efficacy and purity, this process was carefully executed and resulted in a highly reliable and effective product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this may compromise its stability and efficacy. Make sure to follow these guidelines to maintain the integrity of the product.
Storage buffer	The storage condition for Rabbit IgG is in a solution of phosphate buffered saline with a pH of 7.4. It is supplemented with 150mM NaCl and 0.02% sodium azide. Additionally, the solution contains 50% glycerol to maintain stability. It is recommended to store the solution at -20 °C. The Rabbit IgG remains stable for a period of 12 months from the date of receipt.
Target
Background	UDPGT is a crucial enzyme that plays a vital role in eliminating potentially dangerous xenobiotics and endogenous molecules from the body. This is achieved by conjugating these compounds with glucuronic acid, making them more soluble and easily excretable. The enzyme has a specific affinity for certain molecules, with eugenol being the primary substrate. Other substrates include 4-methylumbelliferone, dihydrotestosterone (DHT), androstane-3-alpha,17-beta-diol (3-alpha-diol), testosterone, and androsterone (ADT). However, different UDPGT isozymes have varying affinities for these substrates, with some being more efficient than others. Understanding the function and specificity of UDPGT is crucial in drug development and toxicity studies.
Tissue specificity	Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate.
Celluar localization	Endoplasmic reticulum;
UniPort	O75795