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Rabbit Anti-SNAPC3 Polyclonal Antibody#abs132819

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Description

Catalog-specification	Delivery time	USD price
abs132819-100ug	1-2 Weeks	301.0
abs132819-50ug	1-2 Weeks	201.0

Overview
catalog	abs132819
Description	The SNAPc complex is an essential component for the efficient transcription of RNA polymerase II and III small-nuclear RNA genes. It plays a crucial role by binding to the proximal sequence element (PSE), a basal promoter element that is not the typical TATA-box found in these genes. The PSE is a common feature shared by both RNA polymerase II and III small-nuclear RNA genes. Moreover, SNAPc is responsible for recruiting two important factors, TBP and BRF2, to the U6 snRNA TATA box. This recruitment facilitates the initiation of transcription and ensures proper regulation of gene expression.
Other names	PTF subunit beta, also known as PSE binding factor subunit beta or SNAPc subunit 3, is a protein involved in the activation of small nuclear RNA (snRNA) transcription. It is a component of the snRNA-activating protein complex, which is responsible for initiating transcription of snRNA genes. PTF subunit beta is encoded by the SNPC3 gene. The snRNA-activating protein complex is a multiprotein complex that recognizes and binds to the proximal sequence element (PSE) of snRNA genes, promoting their transcription. PTF subunit beta plays a crucial role in this process by interacting with other subunits of the complex. The PTF subunit beta protein is approximately 50 kDa in size and is essential for the formation and stability of the snRNA-activating protein complex. It is involved in the recruitment of RNA polymerase II to the snRNA gene promoter, initiating the transcription process. Studies have shown that mutations in the SNPC3 gene can result in impaired snRNA transcription and lead to developmental abnormalities and neurodegenerative disorders. Therefore, understanding the function and regulation of PTF subunit beta is important for unraveling the molecular mechanisms underlying these diseases. In conclusion, PTF subunit beta is a critical component of the snRNA-activating protein complex and is involved in the activation of snRNA transcription. Its role in gene expression regulation highlights its significance in various cellular processes and its potential implications in human diseases.
Source	Rabbit
Specificity	The SNAPC3 antibody is capable of detecting the total SNAPC3 levels that are present in the body naturally. This information can be useful in a variety of research applications, as it provides a way to measure this protein and its role in different physiological processes. By using this antibody, scientists can better understand how SNAPC3 functions and potentially develop new treatments or therapies for conditions that involve this protein. Overall, the ability to detect endogenous levels of total SNAPC3 is an important tool for researchers who are interested in studying this protein and its role in the body.
Species Reactivity	Human
Antigen	SNAPC3
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB is typically diluted at a range of 1:500 to 1:2000, IHC at a range of 1:50 to 1:200, and ELISA (peptide) at a range of 1:20000 to 1:40000. It is important to note that these dilution ranges may vary depending on the specific experiment and the target protein being analyzed.
Immunogen	A synthesized peptide.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Celluar localization	Nucleus;
UniPort	Q92966