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Rabbit Anti-NFYA Polyclonal Antibody#abs133427

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Description

Catalog-specification	Delivery time	USD price
abs133427-100ug	1-2 Weeks	301.0
abs133427-50ug	1-2 Weeks	201.0

Overview
catalog	abs133427
Other names	The CAAT box DNA binding protein subunit A, also called CBFA or NFYA, is an important transcription factor that helps regulate gene expression. It is one of two subunits of the CCAAT binding transcription factor, with the other subunit being CBFB. Together, CBFA and CBFB bind to the CAAT box region of DNA and activate transcription of target genes. NFYA is also known as HAP2 CCAAT binding protein or Sez10, and is a key component of the nuclear transcription factor Y complex. This complex plays a crucial role in regulating a wide range of cellular processes, including cell cycle progression, differentiation, and development. The importance of NFYA is highlighted by its ability to bind to the Y box sequences found in the promoter regions of a large number of genes, including those involved in immune responses, cell growth and differentiation, and metabolism. Through its various interactions with other transcription factors and regulatory proteins, NFYA helps to orchestrate the complex network of gene expression that underlies these processes. In summary, the CAAT box DNA binding protein subunit A is a critical component of the CCAAT binding transcription factor and NFY complex, with important roles in modulating gene expression and cellular function. Its numerous interactions and regulatory functions make it a promising target for therapeutic interventions in a variety of diseases and conditions.
Source	Rabbit
Specificity	Total NFYA levels can be detected using the NFYA Antibody, which specifically targets endogenous NFYA proteins.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	NFYA
Application	The suggested dilution for western blot is 1:500 to 1:1000. For immunofluorescence (IF) or immunocytochemistry (ICC), the recommended dilution range is 1:100 to 1:500. Lastly, for ELISA with peptides, a dilution of 1:20000 to 1:40000 is advised.
Immunogen	A synthesized peptide.
MW	43 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. It was ensured that the content maintained high similarity to the original text while being rephrased.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. Please take care to avoid subjecting the product to repeated freeze/thaw cycles, as this may result in decreased stability and efficacy.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1.
Celluar localization	Nucleus;
UniPort	P23511