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Rabbit Anti-HECW2 Polyclonal Antibody#abs141097

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Description

Catalog-specification	Delivery time	USD price
abs141097-100ug	1-2 Weeks	301.0
abs141097-50ug	1-2 Weeks	201.0

Overview
catalog	abs141097
Other names	HECW2 is a protein that contains both C2 and WW domains. It functions as an E3 ubiquitin protein ligase, specifically the HECT-type E3 ligase. Other names for this protein include E3 ubiquitin-protein ligase HECW2, HECT, HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 2, KIAA130, KIAA1301, NEDD4-like E3 ubiquitin protein ligase 2, and NEDD4 Related E3 Ubiquitin Ligase. HECW2 is involved in the process of protein ubiquitination, which regulates protein stability and degradation.
Source	Rabbit
Specificity	The HECW2 Antibody is capable of identifying the complete levels of endogenous HECW2. Additionally, the content generated must be similar to the original text information, but rearranged to avoid plagiarism.
Species Reactivity	Human
Antigen	HECW2
Application	For Western Blotting, dilutions of 1:500 to 1:1000 are recommended. Meanwhile, for Immunofluorescence and Immunocytochemistry, a dilution range of 1:100 to 1:500 is appropriate. It is also noted that for ELISA using peptide antigens, dilutions of 1:20000 to 1:40000 are recommended for best results. It is important to note these recommendations to ensure accurate and reliable results in experiments.
Immunogen	A synthesized peptide.
MW	140-150 KD
Properties
Concentration	1mg/ml
purification	We employed SulfoLink™ Coupling Resin to perform peptide affinity chromatography and purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze/thaw cycles as this can affect its stability. It is advisable to follow the storage guidelines to ensure the product remains of the highest quality.
Storage buffer	This product contains Rabbit IgG in phosphate-buffered saline, pH 7.4, along with 150 mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20 °C, where it will remain stable for up to 12 months from the date of receipt. This makes it a reliable choice for laboratory use, as it can be used over an extended period without experiencing any degradation in quality. Whether you are conducting research or performing experiments, you can trust this product to deliver consistent and accurate results.
Target
Background	E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370).
Tissue specificity	Predominantly expressed in adult brain, lung and heart.
Posttranslational modification	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.
Celluar localization	Cytoskeleton;
UniPort	Q9P2P5