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Rabbit Anti-PVRL1 Polyclonal Antibody#abs136291

Description

Catalog-specification	Delivery time	USD price
abs136291-100ug	1-2 Weeks	301.0
abs136291-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136291
Description	Epithelial and endothelial cells rely on a specific gene to maintain the integrity of their adherens junctions and tight junctions. This gene encodes an adhesion protein that functions as a calcium(2+)-independent cell-cell adhesion molecule. Belonging to the immunoglobulin superfamily, this protein possesses three extracellular immunoglobulin-like loops. It also contains a single transmembrane domain (in some isoforms) and a cytoplasmic region. The protein serves as a receptor for glycoprotein D (gD) present in herpes simplex viruses 1 and 2 (HSV-1, HSV-2), as well as pseudorabies virus (PRV). Its interaction with these viruses facilitates their entry into epithelial and neuronal cells. Notably, mutations in this gene give rise to cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1), as well as non-syndromic cleft lip with or without cleft palate (CL/P). Multiple transcript variants of this gene exist due to alternative splicing, resulting in proteins with distinct C-termini. This information is sourced from RefSeq, as of October 2009.
Other names	PVRL1, also known as CD111 or Herpes virus entry mediator C (HveC), is a protein associated with various medical conditions such as ectodermal dysplasia 4 (Margarita Island type) and orofacial cleft 7 (OFC7). It is also referred to as Nectin-1 or poliovirus receptor-related protein 1 (PRR1). PVRL1 plays a role in herpesvirus entry and is characterized by its Ig-like receptor structure. Other names for PVRL1 include HIgR, MGC142031, OTTHUMP00000232093, OTTHUMP00000232094, OTTHUMP00000232095, and SK-12.
Source	Rabbit
Specificity	The PVRL1 Antibody is capable of detecting the total levels of PVRL1 within the body that have developed naturally. To produce new content based on the original text information, the generated text should be completely different from the style and content generated by ChapGPT.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse
Antigen	PVRL1
Application	The dilution ranges for WB, IHC, IF/ICC, and ELISA (peptide) are as follows: WB dilution range is 1:500-1:2000, IHC dilution range is 1:50-1:200, IF/ICC dilution range is 1:100-1:500, and ELISA (peptide) dilution range is 1:20000-1:40000. These dilution ranges are typically used for different assays to ensure optimal detection of the target protein.
Immunogen	A synthesized peptide derived from human PVRL1.
MW	57kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q15223