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Rabbit Anti-PSMF1 Polyclonal Antibody#abs136906

Description

Catalog-specification	Delivery time	USD price
abs136906-100ug	1-2 Weeks	301.0
abs136906-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136906
Other names	Proteasome inhibitors play a critical role in regulating intracellular protein degradation and are essential for maintaining protein homeostasis. Among these inhibitors, hPI31 (proteasome inhibitor subunit 1) stands out as a vital subunit of the proteasome macropain complex. It functions as a chaperone to stabilize the assembly of the 20S core proteasome, thereby regulating its activity. The gene encoding for hPI31 is also known as PSMF1 or PSMB2, and it is located on chromosomes RP23 402M7.5 and RP4 545L17.1, respectively. A deeper understanding of hPI31's role and its structure may provide insights into the regulation of the proteasome's activity and lead to the development of novel strategies for managing various diseases where protein degradation is dysregulated.
Source	Rabbit
Specificity	The PSMF1 Antibody is specifically designed to recognize and measure the levels of total PSMF1 protein in the body. It is capable of detecting the endogenous levels of PSMF1, providing valuable information about its presence and quantity. This antibody serves as a powerful tool in the study of PSMF1 and its role in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	PSMF1
Application	For western blotting, the recommended dilution range is between 1:500 to 1:2000. When it comes to immunohistochemistry, the optimal dilution range is between 1:50 to 1:200. For ELISA using peptides, a dilution range of 1:20000 to 1:40000 works best. It's important to follow the recommended dilution range to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human PSMF1.
MW	29kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was used in peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	The storage recommendation for this product is to keep it at -20 °C for a duration of one year, while ensuring it does not undergo repeated freeze/thaw cycles. It is important to follow these guidelines to maintain the quality and effectiveness of the product.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be kept in phosphate-buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C. The antibody is stable for a period of 12 months starting from the date of receipt.
Target
Background	Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Celluar localization	Cytosol;Endoplasmic reticulum;Nucleus;
UniPort	Q92530