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Rabbit Anti-TFCP2 Polyclonal Antibody#abs136907

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Description

Catalog-specification	Delivery time	USD price
abs136907-100ug	1-2 Weeks	301.0
abs136907-50ug	1-2 Weeks	201.0

Overview
catalog	abs136907
Description	The alpha-globin gene, which is activated by a transcription factor encoded by this gene, is controlled and regulated by the protein it produces. This transcription factor not only influences the expression of erythroid genes but also plays a crucial role in the switch of globin gene promoters. Apart from its involvement in activating numerous cellular and viral gene promoters, it interacts with specific factors accountable for inflammatory responses. Furthermore, it is worth noting that certain variations in this gene might have a connection with the development of Alzheimer's disease.
Other names	The alpha globin transcription factor CP2, also known as LBP1C, LSF, TFCP2, or SEF, is a crucial regulatory protein that plays a vital role in gene expression. This transcription factor is involved in several important biological processes, such as cell proliferation, differentiation, and apoptosis. It interacts with DNA and other transcription factors, enabling the transcription of specific genes. CP2 is a late SV40 (Simian virus 40) factor, and its expression is induced by several stimuli, such as cytokines, hormones, and growth factors. This factor also binds to the SAA3 enhancer and regulates the synthesis of serum amyloid A3, an acute-phase reactant protein. Transcription factor LSF is an alternate name for CP2, and it is expressed in various tissues and cell types, including the brain, gonads, and immune system. TFCP2C is a specific isoform of the CP2 protein, and it is involved in the regulation of the HSP70 promoter. In summary, CP2 is a critical transcription factor that plays essential roles in the regulation of gene expression and cellular processes. Its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. Understanding its precise mechanisms of action can provide valuable insights into the development of novel therapeutic strategies.
Source	Rabbit
Specificity	The TFCP2 Antibody is capable of detecting total TFCP2 at endogenous levels. This means that it can accurately identify the presence of TFCP2 within an organism without the need for additional markers or indicators. With its ability to recognize total TFCP2, this antibody is an ideal tool for scientists and researchers who are studying this protein and its role in various biological processes. By using this antibody, they can gain a better understanding of how TFCP2 functions, which could ultimately lead to new diagnoses, treatments, and therapies for a range of health conditions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	TFCP2
Application	For western blotting, a dilution ratio of 1:500 to 1:2000 is recommended. When it comes to immunohistochemistry, a range of 1:50 to 1:200 can be used. For ELISA with peptides, the recommended range of dilution is 1:20,000 to 1:40,000. These are the suggested dilution ratios for achieving accurate and reliable results in these experimental techniques.
Immunogen	A synthesized peptide derived from human TFCP2.
MW	57kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. The process resulted in the isolation of a highly purified antiserum with an exceptional binding affinity to the target peptide.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
Tissue specificity	Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level).
Celluar localization	Cytosol;Nucleus;
UniPort	Q12800