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Rabbit Anti-PSMA7 Polyclonal Antibody#abs137751

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Description

Catalog-specification	Delivery time	USD price
abs137751-100ug	1-2 Weeks	301.0
abs137751-50ug	1-2 Weeks	201.0

Overview
catalog	abs137751
Other names	Proteasome alpha 7 subunit, also known as proteasome (prosome macropain) subunit alpha type 7 or proteasome subunit alpha type-7, belongs to the PSMA family. It is encoded by the PSMA7 gene and commonly referred to as PSA7_HUMAN or PSMA7. Another name for this subunit is proteasome subunit alpha 4. It is also denoted as RC6 1 or RC6-1 and XAPC7. To engage in a distinct manner, I will now generate a text that is not derived directly from the original information provided.
Source	Rabbit
Specificity	The presence of total PSMA7 can be accurately detected using the PSMA7 Antibody, which is able to target and detect endogenous levels of the protein. It is designed to specifically recognize and bind to PSMA7, allowing for the reliable measurement of its levels in a sample. This antibody is a valuable tool for researchers studying PSMA7 and its implications in various biological processes. By utilizing the PSMA7 Antibody, scientists can gain insights into the role and regulation of PSMA7 in cellular activities and disease mechanisms.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Chicken;Pig;Dog;Horse;Sheep;Bovine
Antigen	PSMA7
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PSMA7.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. This ensured high levels of purity in the final product.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store the product at -20 °C for a duration of one year. To maintain its quality, please avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
Tissue specificity	Down-regulated by the ribozyme Rz3'X. Up-regulated in colorectal cancer tissues.
Posttranslational modification	Phosphorylation by ABL1 or ABL2 leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	O14818